Literature DB >> 6796303

The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine.

S Aanderud, O L Myking, R E Strandjord.   

Abstract

Carbamazepine (CBZ) decreases the serum concentration of thyroid hormones. It is proposed that CBZ increases the extra-thyroidal metabolism of thyroid hormones. In order to test this hypothesis CBZ was given to nine hypothyroid patients substituted with thyroxine (T4). A significant decrease in serum concentrations of T4, calculated free T4 (FT4), triiodothyronine (T3), and calculated free T3(FT3) was found after 3 weeks of CBZ medication. The serum concentrations of TSH and the T4:T3 ratios were unaltered, while the serum concentrations of T4-binding globulin (TBG) increased markedly in eight of the nine patients. These findings support the hypothesis of a CBZ induced increase in the extra-thyroidal metabolism of thyroid hormones.

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Year:  1981        PMID： 6796303     DOI： 10.1111/j.1365-2265.1981.tb00662.x

Source DB:  PubMed          Journal:  Clin Endocrinol (Oxf)        ISSN： 0300-0664            Impact factor:   3.478


  6 in total

1.  Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.

Authors:  Jacqueline Jonklaas; Antonio C Bianco; Andrew J Bauer; Kenneth D Burman; Anne R Cappola; Francesco S Celi; David S Cooper; Brian W Kim; Robin P Peeters; M Sara Rosenthal; Anna M Sawka
Journal:  Thyroid       Date:  2014-12       Impact factor: 6.568

2.  Changes in thyroid function tests induced by 2 month carbamazepine treatment in L-thyroxine-substituted hypothyroid children.

Authors:  F De Luca; T Arrigo; E Pandullo; M F Siracusano; S Benvenga; F Trimarchi
Journal:  Eur J Pediatr       Date:  1986-04       Impact factor: 3.183

3.  Thyroid hormone concentrations in epileptic patients.

Authors:  J G Larkin; G J Macphee; G H Beastall; M J Brodie
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

4.  Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine.

Authors:  J M Connell; W G Rapeport; S Gordon; M J Brodie
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

5.  The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.

Authors:  A A Connacher; D Q Borsey; M C Browning; D L Davidson; R T Jung
Journal:  Postgrad Med J       Date:  1987-10       Impact factor: 2.401

6.  Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients.

Authors:  J I Isojärvi; K E Airaksinen; M Repo; A J Pakarinen; P Salmela; V V Myllylä
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-06       Impact factor: 10.154
  6 in total

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