Literature DB >> 67953

The induction of specific resistance in F1 hybrid rats to local graft-vs.-host reactions: nature of the eliciting cell.

R T Woodland, D B Wilson.   

Abstract

A specific state of resistance to local graft-vs.-host (GVH) reactions can be induced in F1 hybrid rats, derived from Ag-B incompatible matings, as a consequence of inoculation with low numbers of parental strain lymphocytes. The magnitude of GVH resistance is markedly and directly dependent upon the number of parental strain lymphocytes used in the pretreatment regimen. The relevant constituents of the resistance-inducing parental cell population are thymus-derived (T) lymphocytes possessing immunologic competence for host alloantigens. B cells, themselves incapable of inducing GVH resistance, adversely effect the induction or display of this effect by T cells.

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Year:  1977        PMID： 67953     DOI： 10.1002/eji.1830070305

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  8 in total

1.  Self Ia-recognizing T cells undergo an ordered series of interactions with Ia-bearing substrate cells of defined function during their development: a model.

Authors:  C A Janeway; M E Katz
Journal:  Surv Immunol Res       Date:  1984

2.  Cytotoxic T-cell precursors revealed in neonatally tolerant mice.

Authors:  B Stockinger
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

3.  Immunogenicity and crossreactivity of specificity-associated markers on alloreactive T cells. Confirmation based on the model of tolerance abolition by adoptive transfer.

Authors:  H Kimura; W K Silvers; D B Wilson
Journal:  J Exp Med       Date:  1986-02-01       Impact factor: 14.307

4.  Immunological studies of T-cell receptors. II. Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex alloantigens.

Authors:  D Bellgrau; D B Wilson
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307

5.  Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.

Authors:  D Bellgrau; D B Wilson
Journal:  J Exp Med       Date:  1978-07-01       Impact factor: 14.307

6.  Analysis of T cell populations that induce and mediate specific resistance to graft-versus-host disease in rats.

Authors:  H Kimura; A Pickard; D B Wilson
Journal:  J Exp Med       Date:  1984-09-01       Impact factor: 14.307

7.  Cyclosporine-induced autoimmunity. Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats.

Authors:  R Sorokin; H Kimura; K Schroder; D H Wilson; D B Wilson
Journal:  J Exp Med       Date:  1986-11-01       Impact factor: 14.307

8.  Induced tolerance in F1 rats to anti-major histocompatibility complex receptors on parental T cells. Implications for self tolerance.

Authors:  D Bellgrau; D Smilek; D B Wilson
Journal:  J Exp Med       Date:  1981-06-01       Impact factor: 14.307
  8 in total

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