Literature DB >> 6795133

Dichloromethane and carbon monoxide inhalation: carboxyhemoglobin addition, and drug metabolizing enzymes in rat.

K Kurppa, H Kivistö, H Vainio.   

Abstract

Male Wistar rats were exposed for 3 h to 100 ppm Co, 1,000 ppm dichloromethane, or to their combination. Exposure to dichloromethane alone or in combination with CO double the ethoxycoumarin O-deethylase activity in the kidney microsomes but not in the liver. An additive effect on blood COHb concentration by simultaneous exposure to CO and dichloromethane was observed. The mechanism of the additive effect is discussed.

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Year:  1981        PMID： 6795133     DOI： 10.1007/BF00380812

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  18 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Paint removers and carboxyhemoglobin.

Authors:  P L Langehennig; R A Seeler; E Berman
Journal:  N Engl J Med       Date:  1976-11-11       Impact factor: 91.245

3.  In vivo conversion of methylene chloride to carbon monoxide.

Authors:  R S Ratney; D H Wegman; H B Elkins
Journal:  Arch Environ Health       Date:  1974-04

4.  Carboxyhemoglobin elevation after exposure to dichloromethane.

Authors:  R D Stewart; T N Fisher; M J Hosko; J E Peterson; E D Baretta; H C Dodd
Journal:  Science       Date:  1972-04-21       Impact factor: 47.728

5.  Effect of dichloromethane on hemoglobin function.

Authors:  H A Collison; F L Rodkey; J D O'Neal
Journal:  Biochem Pharmacol       Date:  1977-03-15       Impact factor: 5.858

6.  Direct fluorometric methods for measuring mixed function oxidase activity.

Authors:  R A Prough; M D Burke; R T Mayer
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

7.  Metabolism of dihalomethanes to carbon monoxide--III. Studies on the mechanism of the reaction.

Authors:  V L Kubic; M W Anders
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

8.  Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies.

Authors:  V L Kubic; M W Anders
Journal:  Drug Metab Dispos       Date:  1975 Mar-Apr       Impact factor: 3.922

9.  Role of blood flow in carbon monoxide- and hypoxic hypoxia-induced alterations in hexobarbital metabolism in rats.

Authors:  R A Roth; R J Rubin
Journal:  Drug Metab Dispos       Date:  1976 Sep-Oct       Impact factor: 3.922

10.  Dichloromethane as an antisickling agent in sickle cell hemoglobin.

Authors:  B P Schoenborn
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205
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