Literature DB >> 6794923

Dose-dependent pharmacokinetics of PMM in the rat.

T Colombo, L Torti, M D'Incalci.   

Abstract

Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 mu g/ml X min; plasma clearances were 0.042 and 0.027 l . kg(-1) . min(-1), respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

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Year:  1981        PMID： 6794923     DOI： 10.1007/BF00258481

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  6 in total

1.  Gas chromatographic determination of hexamethylmelamine in mouse plasma.

Authors:  M D'Incalci; P Morazzoni; C Pantarotto
Journal:  Anal Biochem       Date:  1979-11-01       Impact factor: 3.365

Review 2.  A modern view of pharmacokinetics.

Authors:  J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1973-10

3.  In vitro studies with hexamethylmelamine.

Authors:  C J Rutty; T A Connors
Journal:  Biochem Pharmacol       Date:  1977-12-15       Impact factor: 5.858

4.  Utilization of metabolic activation for in vitro screening of potential antineoplastic agents.

Authors:  M L Meltz; D W Winters
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

5.  Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans.

Authors:  M M Ames; G Powis; J S Kovach; R T Eagan
Journal:  Cancer Res       Date:  1979-12       Impact factor: 12.701

6.  Pharmacokinetics of hexamethylmelamine and pentamethylmelamine in mice.

Authors:  M Broggini; T Colombo; M D'Incalci; M G Donnelli; A Gescher; S Garattini
Journal:  Cancer Treat Rep       Date:  1981 Jul-Aug
  6 in total
  1 in total

1.  Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors.

Authors:  J Dubois; G Atassi; M Hanocq; F Abikhalil
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333
  1 in total

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