Literature DB >> 679398

Distribution of a platinum anti-tumour drug in HeLa cells by analytical electron microscopy.

M U Khan, P J Sadler.   

Abstract

The distribution of Pt in HeLa cell sections after cell treatment with cis-Pt(NH3)2Cl2 dissolved in dimethylsulphoxide was probed by analytical electron microscopy. Primary targets were the nucleolus and the inner side of the nuclear double membrane. Even after solvolysis in dimethylsulphoxide the drug reached similar sites. It is suggested that cell death may be due to Pt inhibition at the initiation sites of DNA synthesis.

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Year:  1978        PMID： 679398     DOI： 10.1016/0009-2797(78)90021-2

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  5 in total

1.  The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.

Authors:  Matthew D Hall; Carolyn T Dillon; Mei Zhang; Philip Beale; Zhonghou Cai; Barry Lai; Anton P J Stampfl; Trevor W Hambley
Journal:  J Biol Inorg Chem       Date:  2003-07-12       Impact factor: 3.358

Review 2.  Binding of kinetically inert metal ions to RNA: the case of platinum(II).

Authors:  Erich G Chapman; Alethia A Hostetter; Maire F Osborn; Amanda L Miller; Victoria J DeRose
Journal:  Met Ions Life Sci       Date:  2011

3.  Specific Interactions of Antitumor Metallocenes with Deoxydinucleoside Monophosphates.

Authors:  Rahel P Eberle; Yvonne Hari; Stefan Schürch
Journal:  J Am Soc Mass Spectrom       Date:  2017-05-12       Impact factor: 3.109

4.  Induction of cell arrest at G1/S and in G2 after treatment of Ehrlich ascites tumor cells with metallocene dichlorides and cis-platinum in vitro.

Authors:  P Köpf-Maier; W Wagner; E Liss
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

5.  Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect.

Authors:  Anton A Legin; Arno Schintlmeister; Nadine S Sommerfeld; Margret Eckhard; Sarah Theiner; Siegfried Reipert; Daniel Strohhofer; Michael A Jakupec; Mathea S Galanski; Michael Wagner; Bernhard K Keppler
Journal:  Nanoscale Adv       Date:  2020-11-26
  5 in total

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