Literature DB >> 6791781

Action of vitamin D metabolites on PTH secretion in man.

L Miravet, J Guéris, J Redel, A Norman, A Ryckewaert.   

Abstract

We have examined the effects of metabolites of vitamin D [25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, and 25,26(OH)2D3] on serum calcium and iPTH in human deficient-D osteomalacia. The four metabolites decreased iPTH, but only for 1,25(OH)2D3 was a significant correlation between increase of serum calcium and decrease of iPTH observed. The 24,25(OH)2D3 and 25,26(OH)2D3 decreased iPTH despite a decrease of serum calcium at the beginning of treatment. The 25OHD decreased iPTH before increased serum calcium. These results could be interpreted as a direct effect of metabolites of vitamin D on PTH secretion. However, the conversion of other metabolites and the calcium concentration in parathyroid cells must be determined before this hypothesis can be accepted.

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Year:  1981        PMID： 6791781     DOI： 10.1007/BF02409436

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  11 in total

1.  Proceedings: Inhibitory effect of 24,25-dihydroxycholecalciferol on parathyroid hormone secretion in the goat.

Authors:  R F Bates; A D Care; M Peacock; E B Mawer; C M Taylor
Journal:  J Endocrinol       Date:  1975-01       Impact factor: 4.286

2.  Studies on the mode of action of calciferol. Subcellular localization of 1,25-dihydroxyvitamin D3 in chicken parathyroid glands.

Authors:  W R Wecksler; H L Henry; A W Norman
Journal:  Arch Biochem Biophys       Date:  1977-09       Impact factor: 4.013

3.  [Effect of vitamin D metabolites on mineralization of bone tissue and phosphocalcium metabolism disorders in the course of vitamin D deficiency osteomalacia].

Authors:  P Bordier; L Miravet; P Marie; J Guéris; F Rousselet; A Norman; H Rasmussen; A Ryckewaert
Journal:  Rev Rhum Mal Osteoartic       Date:  1978-04

4.  [The synthesis of dihydroxy-25,26 cholecalciferol, a metabolite of vitamin D3].

Authors:  J Redel; P Bell; F Delbarre; E Kodicek; M J Tréfouël
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1973-05-21

5.  Control of 25-hydroxycholecalciferol metabolism by parathyroid glands.

Authors:  M Garabedian; M F Holick; H F Deluca; I T Boyle
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

6.  The biological activity and metabolism of 24,25-dihydroxyvitamin D 3 .

Authors:  I T Boyle; J L Omdahl; R W Gray; H F DeLuca
Journal:  J Biol Chem       Date:  1973-06-25       Impact factor: 5.157

7.  The action of vitamin D metabolites (25 OHD3--12,5 (OH)2D3--24.25 (OH)2D3--25.26 (OH)2D3) on vitamin D deficient rats.

Authors:  M L Queille; L Miravet; P Bordier; J Redel
Journal:  Biomedicine       Date:  1978 Jul-Aug

8.  [The estimation of parathormone in primary hyperparathyroidism (author's transl)].

Authors:  C Dubost; P J Bordier; J Ferry; J Gueris
Journal:  Nouv Presse Med       Date:  1978-01-07

9.  [The effects of two metabolites of vitamin D3, dihydroxy-24,25 cholecalciferol and dihydroxy-25,26 cholecalciferol, on the metabolism of calcium in rats].

Authors:  G Milhaud; M M Labat; J Redel; M Fontaine
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1974-09

10.  Radioimmunoassay of human parathyroid hormone in serum.

Authors:  C D Arnaud; H S Tsao; T Littledike
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808
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