Literature DB >> 6791593

Gonadotrophin response to LH-RH in boys with delayed growth and adolescence.

M O Savage, M A Preece, N Cameron, J Jones, G Theintz, J L Penfold, J M Tanner.   

Abstract

Plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations were measured before and after intravenous luteinising hormone-releasing hormone (LH-RH) in 33 boys with growth delay. Eighteen were prepubertal and 15 pubertal. Basal LH and FSH levels were low in both groups with mean increments after LH-RH of 3.2 +/- 0.8 U/l (mean +/- SEM) and 2.6 +/- 0.4 U/l respectively in the prepubertal and 7.4 +/- 0.7 U/l and 2.0 +/- 0.3 U/l in the pubertal boys. The LH increment showed a positive correlation with increasing bone age (r = 0.71, P less than 0.001); FSH did not. The LH-RH response thus appeared normal in relation to the stage of maturity.

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Year:  1981        PMID: 6791593      PMCID: PMC1627372          DOI: 10.1136/adc.56.7.552

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  18 in total

1.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

Review 2.  Endocrinology in preadolescents and adolescents. I. Hormonal changes during normal puberty.

Authors:  P C Sizonenko
Journal:  Am J Dis Child       Date:  1978-07

Review 3.  The use of luteinizing hormone-releasing hormone in pediatric patients.

Authors:  J C Job; J L Chaussain; P E Garnier
Journal:  Horm Res       Date:  1977

4.  Growth delay.

Authors:  M A Preece
Journal:  Acta Paediatr Belg       Date:  1979 Jan-Mar

5.  Heterogeneity of gonadotropin response to LHRH in hypogonadotropic hypogonadism.

Authors:  J Bell; I Spitz; A Perlman; S Segal; Z Palti; D Rabinowitz
Journal:  J Clin Endocrinol Metab       Date:  1973-04       Impact factor: 5.958

6.  Hormonal changes in puberty. 3. Correlation of plasma testosterone, LH, FSH, testicular size, and bone age with male pubertal development.

Authors:  G P August; M M Grumbach; S L Kaplan
Journal:  J Clin Endocrinol Metab       Date:  1972-02       Impact factor: 5.958

7.  Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty, testicular size, and bone age in normal boys.

Authors:  I M Burr; P C Sizonenko; S L Kaplan; M M Grumbach
Journal:  Pediatr Res       Date:  1970-01       Impact factor: 3.756

8.  LH and FSH responsiveness to intravenous gonadotropin-releasing hormone (GnRH) in children with hypothalamic or pituitary disorders: lack of effect of replacement therapy with human growth hormone.

Authors:  R P Kelch; M Markovs; J Huss
Journal:  J Clin Endocrinol Metab       Date:  1976-06       Impact factor: 5.958

9.  Response of plasma LH and FSH to synthetic LH-RH in children at various pubertal stages.

Authors:  Z Dickerman; R Prager-Lewis; Z Laron
Journal:  Am J Dis Child       Date:  1976-06

10.  The effect of hypothalamic luteinizing hormone releasing hormone (LH-RH) on plasma gonadotrophin levels in normal subjects.

Authors:  P Franchimont; H Becker; C Ernould; C Thys; A Demoulin; J P Bourguignon; J J Legros; J C Valcke
Journal:  Clin Endocrinol (Oxf)       Date:  1974-01       Impact factor: 3.478

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  4 in total

1.  Growth and pubertal development in five boys with Noonan's syndrome.

Authors:  G Theintz; M O Savage
Journal:  Arch Dis Child       Date:  1982-01       Impact factor: 3.791

2.  Endocrine function, morbidity, and mortality after surgery for craniopharyngioma.

Authors:  K R Lyen; D B Grant
Journal:  Arch Dis Child       Date:  1982-11       Impact factor: 3.791

3.  Transient sexual precocity and ovarian cysts.

Authors:  A J Lyon; R De Bruyn; D B Grant
Journal:  Arch Dis Child       Date:  1985-09       Impact factor: 3.791

4.  Role of Gonadotropin-releasing Hormone Stimulation Test in Diagnosing Gonadotropin Deficiency in Both Males and Females with Delayed Puberty.

Authors:  Qi-Hong Sun; Yu Zheng; Xiao-Lin Zhang; Yi-Ming Mu
Journal:  Chin Med J (Engl)       Date:  2015-09-20       Impact factor: 2.628

  4 in total

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