Literature DB >> 6791482

Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C.

R W Randall, K E Eakins, G A Higgs, J A Salmon, J E Tateson.   

Abstract

Arachidonic acid is metabolized via two pathways in leukocytes: cyclo-oxygenase, leading to the stable prostaglandins, and lipoxygenase, leading to hydroxyacids. Indomethacin inhibits the cyclo-oxygenase selectively, whereas compound BW755C (3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline) inhibits both pathways equally. This offers a possible explanation for the differing activities of these two compounds in inflammatory models in vivo. The patterns of product inhibition by the two compounds support the suggestion that 11-HETE (hydroxy-eicosate-traenoic acid) and 15-HETE can arise by incomplete operation of the cyclo-oxygenase pathway.

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Year:  1980        PMID： 6791482     DOI： 10.1007/BF02024164

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  5 in total

1.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

2.  Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets.

Authors:  S R Turner; J A Tainer; W S Lynn
Journal:  Nature       Date:  1975-10-23       Impact factor: 49.962

3.  Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates.

Authors:  M I Siegel; R T McConnell; N A Porter; J L Selph; J F Truax; R Vinegar; P Cuatrecasas
Journal:  Biochem Biophys Res Commun       Date:  1980-01-29       Impact factor: 3.575

4.  Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.

Authors:  P Borgeat; M Hamberg; B Samuelsson
Journal:  J Biol Chem       Date:  1976-12-25       Impact factor: 5.157

5.  Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

Authors:  R C Murphy; S Hammarström; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205
  5 in total
  16 in total

1.  The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.

Authors:  W Kreutner; J Sherwood; C Rizzo
Journal:  Agents Actions       Date:  1989-11

2.  Stimulation and inhibition of prostacyclin formation in the gastric mucosa and ileum in vitro by anti-inflammatory agents.

Authors:  N K Boughton-Smith; B J Whittle
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

3.  Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits.

Authors:  N Berend; C L Armour; J L Black
Journal:  Agents Actions       Date:  1986-08

4.  Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C.

Authors:  G A Higgs; K G Mugridge; S Moncada; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

5.  Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors.

Authors:  P A Ward; M C Sulavik; K J Johnson
Journal:  Am J Pathol       Date:  1984-08       Impact factor: 4.307

6.  5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein.

Authors:  W Jessup; V Darley-Usmar; V O'Leary; S Bedwell
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

7.  Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs.

Authors:  N Hudson; M Balsitis; S Everitt; C J Hawkey
Journal:  Gut       Date:  1993-06       Impact factor: 23.059

8.  Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

Authors:  N K Boughton-Smith; C J Hawkey; B J Whittle
Journal:  Gut       Date:  1983-12       Impact factor: 23.059

9.  Interference of anti-inflammatory and anti-asthmatic drugs with neutrophil-mediated platelet activation: singularity of azelastine.

Authors:  P Renesto; V Balloy; B B Vargaftig; M Chignard
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

10.  Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression.

Authors:  S L Kunkel; S W Chensue; M Plewa; G I Higashi
Journal:  Am J Pathol       Date:  1984-02       Impact factor: 4.307
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