Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance.

Literature DB >> 6791286

Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance.

A Naji, W K Silvers, D Bellgrau, C F Barker.

Abstract

Spontaneous diabetes occurring in "BB" rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an autoimmune etiology. Evidence is presented that islets transplanted to diabetic BB rats are destroyed by the original disease process. Inoculation of bone marrow from normal (nondiabetes-susceptible) rat donors into neonatal BB recipients usually prevented the development of hyperglycemia.

Entities: Chemical Disease Species

Mesh：

Year: 1981 PMID： 6791286 DOI： 10.1126/science.6791286

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

21 in total

1. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1986-10 Impact factor: 4.307

Review 2. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.

Authors: Xiaolun Huang; Daniel J Moore; Robert J Ketchum; Craig S Nunemaker; Boris Kovatchev; Anthony L McCall; Kenneth L Brayman
Journal: Endocr Rev Date: 2008-07-29 Impact factor: 19.871

3. In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

Authors: C Boitard; S Michie; P Serrurier; G W Butcher; A P Larkins; H O McDevitt
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1988-08 Impact factor: 4.307

Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance.

1. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Review 2. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.

3. In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

Review 4. Disordered cellular immunity in type I diabetes of man and the BB rat.

Review 5. Altered immunity and diabetes in the BB rat.

6. Immunologic factors in pathogenesis and treatment of human and animal diabetes.

7. Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

8. Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat.

Review 9. The role of immunotherapy in type I diabetes mellitus.

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.