The anticonvulsant effect of phencyclidine in rats.

Phencyclidine hydrochloride (PCP), injected subcutaneously into rats 30 min before exposure to the chemical convulsant flurothyl, raised seizure thresholds in a dose-related manner. The narcotic antagonist naloxone was ineffective in blocking the PCP-induced effect. This anti-convulsant property of PCP is like that previously reported for the narcotic agonist-antagonists cyclazocine and SKF 10,047 (N-allylnormetazocine), which also resemble PCP in their ability to induce psychotomimetic behavior. The data support the idea that these three drugs act on the same receptors.