Literature DB >> 6789356

Use of simple tasks to test for impairment of complex skills by a sedative.

E H Ellinwood, M Linnoila, H V Angle, J W Moore, J T Skinner, M Easler, D W Molter.   

Abstract

Examination of the effect of three doses of pentobarbital on the comparative performance of a complex psychomotor task with two simple neuromotor tasks, i. e., standing steady and pendulum eye tracking, revealed a high correlation. These simple tasks could be used as measures of intoxication since they do not require extensive training. Examination of the complex task impairment blood level ratio revealed that impairment relative to blood level was much greater in the absorption phase. This changing ratio underscores the point that blood levels alone are not an adequate estimate of intoxication.

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Year:  1981        PMID: 6789356     DOI: 10.1007/BF00426464

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN: 0033-3158            Impact factor:   4.530


  24 in total

1.  Action of a barbiturate drug (amylobarbitone sodium) on the vestibulo-ocular reflex.

Authors:  C RASHBASS; G F RUSSELL
Journal:  Brain       Date:  1961-06       Impact factor: 13.501

2.  A measurable neurophysiological factor of psychiatric significance.

Authors:  C SHAGASS
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1957-02

3.  Traffic accidents and psychomotor test performance. A follow-up study.

Authors:  S Häkkinen
Journal:  Mod Probl Pharmacopsychiatry       Date:  1976

4.  Effects of alcohol on peripheral vision as a function of attention.

Authors:  H Moskowitz; S Sharma
Journal:  Hum Factors       Date:  1974-04       Impact factor: 2.888

5.  Dynamic visual acuity, eye movements and peripheral acuity for moving targets.

Authors:  B Brown
Journal:  Vision Res       Date:  1972-02       Impact factor: 1.886

6.  Effects of alcoholic beverages and congeners on psychomotor skills in old and young subjects.

Authors:  A S Wilson; J J Barboriak; W A Kass
Journal:  Q J Stud Alcohol       Date:  1970-05

7.  Analysis of growth and dose response curves.

Authors:  J E Grizzle; D M Allen
Journal:  Biometrics       Date:  1969-06       Impact factor: 2.571

8.  Smooth-pursuit eye movements: a comparison of two measurement techniques for studying schizophrenia.

Authors:  D T Lindsey; P S Holzman; S Haberman; N J Yasillo
Journal:  J Abnorm Psychol       Date:  1978-10

9.  Skills related to driving after intravenous diazepam, flunitrazepam or droperidol.

Authors:  K Korttila; M Linnoila
Journal:  Br J Anaesth       Date:  1974-12       Impact factor: 9.166

10.  The effects of alcohol and of varying amounts of visual information on a balancing test.

Authors:  G H Begbie
Journal:  Ergonomics       Date:  1966-07       Impact factor: 2.778

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  4 in total

1.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. I: Lorazepam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

2.  Profile of acute tolerance to three sedative anxiolytics.

Authors:  E H Ellinwood; M Linnoila; M E Easler; D W Molter
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

3.  Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood.

Authors:  M M Ghoneim; S P Mewaldt; J V Hinrichs
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance.

Authors:  A M Nikaido; E H Ellinwood
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

  4 in total

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