Literature DB >> 6788890

Nucleic acid and protein sequences of phosphocholine-binding light chains.

S P Kwan, S Rudikoff, J G Seidman, P Leder, M D Scharff.   

Abstract

An 18-kilobase DNA fragment containing the sequence coding for both the variable and constant regions of the S107 mouse immunoglobulin light chain was cloned from total cellular DNA. The complete nucleotide sequence of the kappa-chain variable-region gene is reported. Determination of the amino acid sequence encoded by the DNA is found to be identical to the protein sequence of the T15 light chain through residue 88. Direct sequence analysis confirmed that the J1 joining segment is used in the recombination event producing the active kappa light chain gene.

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Year:  1981        PMID： 6788890      PMCID： PMC2186162          DOI： 10.1084/jem.153.5.1366

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  kappa Chain variable region from M167, a phosphorylcholine binding myeloma protein.

Authors:  S Rudikoff; M Potter
Journal:  Biochemistry       Date:  1978-07-11       Impact factor: 3.162

2.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

3.  Antigen-binding mutants of mouse myeloma cells.

Authors:  W D Cook; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

5.  Charon phages: safer derivatives of bacteriophage lambda for DNA cloning.

Authors:  F R Blattner; B G Williams; A E Blechl; K Denniston-Thompson; H E Faber; L Furlong; D J Grunwald; D O Kiefer; D D Moore; J W Schumm; E L Sheldon; O Smithies
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

6.  Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

Authors:  S Rudikoff; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

7.  High capacity gel preparative electrophoresis for purification of fragments of genomic DNA.

Authors:  F Polsky; M H Edgell; J G Seidman; P Leder
Journal:  Anal Biochem       Date:  1978-07-01       Impact factor: 3.365

Review 8.  The response to phosphorylcholine: dissecting an immune response.

Authors:  H Köhler
Journal:  Transplant Rev       Date:  1975

9.  Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine.

Authors:  P Barstad; S Rudikoff; M Potter; M Cohn; W Konigsberg; L Hood
Journal:  Science       Date:  1974-03-08       Impact factor: 47.728

10.  Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies.

Authors:  J L Claflin; J M Davie
Journal:  J Exp Med       Date:  1974-09-01       Impact factor: 14.307
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  20 in total

1.  Recombinant antibody-metallothionein: design and evaluation for radioimmunoimaging.

Authors:  C Das; P V Kulkarni; A Constantinescu; P Antich; F R Blattner; P W Tucker
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

2.  neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation.

Authors:  J G Flanagan; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

3.  Complete sequence of a cDNA clone specifying sandbar shark immunoglobulin light chain: gene organization and implications for the evolution of light chains.

Authors:  V S Hohman; S F Schluter; J J Marchalonis
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

4.  Enhanced transcription of the 78,000-dalton glucose-regulated protein (GRP78) gene and association of GRP78 with immunoglobulin light chains in a nonsecreting B-cell myeloma line (NS-1).

Authors:  T Nakaki; R J Deans; A S Lee
Journal:  Mol Cell Biol       Date:  1989-05       Impact factor: 4.272

5.  The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6.

Authors:  K S Hatton; C L Schildkraut
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

6.  Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases.

Authors:  Zhe Liu; William T Garrard
Journal:  Mol Cell Biol       Date:  2005-04       Impact factor: 4.272

7.  Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

Authors:  B Diamond; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.

Authors:  O Bernard; N M Gough; J M Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Single amino acid substitution altering antigen-binding specificity.

Authors:  S Rudikoff; A M Giusti; W D Cook; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

10.  Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

Authors:  S L Morrison; M J Johnson; L A Herzenberg; V T Oi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205
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