Literature DB >> 6788682

Free immunoglobulin light chain synthesis by human foetal liver and cord blood lymphocytes.

A C Hannam-Harris, J L Smith.   

Abstract

Immunoglobulin (Ig) synthesis by immature B lymphocytes from human foetal liver and cord blood has been investigated. Seven out of fifteen preparations of foetal liver cells and eight out of eleven cord bloods synthesized Ig detectable by biosynthetic labelling. All cultures of foetal lymphocytes with detectable Ig synthesis secreted free light chain. Two of these cases also synthesized free mu heavy chain. Cord blood lymphocyte synthesis patterns were variable ranging from free light chain as the only secreted Ig product to balanced synthesis of heavy and light chains. No cord blood cultures synthesized detectable free mu chains. Free Ig-light-chain synthesis appears to be associated with normal immature B lymphocytes and the results are discussed in relation to the B-cell differentiation pathway.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6788682      PMCID： PMC1555063     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  14 in total

1.  Evidence that murine pre-B cells synthesise mu heavy chains but no light chains.

Authors:  P Burrows; M LeJeune; J F Kearney
Journal:  Nature       Date:  1979-08-30       Impact factor: 49.962

2.  Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes.

Authors:  R P Perry; D E Kelley
Journal:  Cell       Date:  1979-12       Impact factor: 41.582

3.  Free immunoglobulin light chain synthesis by lymphocytes from patients with hypogammaglobulinaemia.

Authors:  J Gordon; J L Smith
Journal:  Clin Exp Immunol       Date:  1978-11       Impact factor: 4.330

4.  Pre-B cells: bone marrow persistence in anti-mu-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamide.

Authors:  P D Burrows; J F Kearney; A R Lawton; M D Cooper
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

5.  Induction of plasma cell differentiation of human fetal lymphocytes: evidence for functional immaturity of T and B cells.

Authors:  A R Hayward; A R Lawton
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

6.  Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans.

Authors:  W E Gathings; A R Lawton; M D Cooper
Journal:  Eur J Immunol       Date:  1977-11       Impact factor: 5.532

7.  Suppression of adult B cell differentiation in pokeweed mitogen-stimulated cultures by Fc(IgG) receptor-negative T cells from cord blood.

Authors:  N Moriya; T Nagaoki; N Okuda; N Taniguchi
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

8.  Early production of intracellular IgM by B-lymphocyte precursors in mouse.

Authors:  M C Raff; M Megson; J J Owen; M D Cooper
Journal:  Nature       Date:  1976-01-22       Impact factor: 49.962

9.  Immunoglobulin expression and synthesis by human haemic cell lines.

Authors:  J Gordon; D Hough; A Karpas; J L Smith
Journal:  Immunology       Date:  1977-04       Impact factor: 7.397

10.  Free light chain synthesis by neoplastic cells in chronic lymphocytic leukaemia and non-Hodgkin's lymphoma.

Authors:  J Gordon; A R Howlett; J L Smith
Journal:  Immunology       Date:  1978-03       Impact factor: 7.397
View more
  5 in total

1.  Urine free light chains in SLE: clonal markers of B-cell activity and potential link to in vivo secreted Ig.

Authors:  J E Hopper; J Golbus; C Meyer; G A Ferrer
Journal:  J Clin Immunol       Date:  2000-03       Impact factor: 8.317

2.  Differences in kappa to lambda (kappa:lambda) ratios of serum and urinary free light chains.

Authors:  M Abe; T Goto; M Kosaka; D Wolfenbarger; D T Weiss; A Solomon
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

3.  Detection of free kappa chains in human serum and urine using pairs of monoclonal antibodies reacting with C kappa epitopes not available on whole immunoglobulins.

Authors:  N R Ling; J Lowe; D Hardie; S Evans; R Jefferis
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330

4.  Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection.

Authors:  Satu Hepojoki; Lauri Kareinen; Tomas Strandin; Antti Vaheri; Harry Holthöfer; Jukka Mustonen; Satu Mäkelä; Klaus Hedman; Olli Vapalahti; Jussi Hepojoki
Journal:  Viruses       Date:  2019-09-01       Impact factor: 5.048

5.  Correlation between Ig-synthesis patterns and lymphoma classification.

Authors:  A C Hannam-Harris; J Gordon; D H Wright; J L Smith
Journal:  Br J Cancer       Date:  1982-08       Impact factor: 7.640
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.