Effect of co-trimoxazole on the glomerular filtration rate of healthy adults.

The administration of co-trimoxazole to 10 healthy adult volunteers was associated with a significant rise in their mean plasma creatinine (by 17.6%: p less than 0.01) and decrease in their mean creatinine clearance (by 26.3%: p less than 0.01). However, glomerular filtration rate (calculated from 51Cr-EDTA clearance) did not show any significant change. It is concluded that the changes in plasma creatinine and creatinine clearance during co-trimoxazole administration are not due to a decrease in glomerular filtration rate.