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Literature DB >> 6787168

Effect of interleukin 1 on human thymocytes and purified human T cells.

A L Maizel, S R Mehta, R J Ford, L B Lachman.

Abstract

Human Interleukin 1 (IL-1) purified by molecular weight fractionation, isoelectric focusing, and gel electrophoresis has been tested on human thymocytes and highly purified human T cells. IL-1 prepared in this manner could not support the long-term growth of T cells yet would augment lectin-stimulated mitogenesis. The IL-1 preparations were shown to possess the lectin-augmenting activity at dilutions containing less than 1 ng of the measurable protein. These data are in agreement with the model that IL-1 stimulates production of IL-2 from lectin-stimulated lymphocytes.

Entities: Gene Species

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Year: 1981 PMID： 6787168 PMCID： PMC2186072 DOI： 10.1084/jem.153.2.470

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

25 in total

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26 in total

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Journal: Proc Natl Acad Sci U S A Date: 1982-10 Impact factor: 11.205

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