Literature DB >> 6786779

[Intestinal lymphatic absorption of labelled oleic acid in the normal rat and rat treated with actidione-cycloheximide or acetoxycycloheximide].

A Bernard, H Carlier.   

Abstract

Actidione-cycloheximide or acetoxycycloheximide treated and control Rats prepared with main mesenteric lymph duct cannulation were infused with a 90 mumol lipid emulsion composed of an equimolar mixture of monopalmitin, palmitic acid and 14C oleic acid and added with bile. In control Rats 75% of 14C oleic was recovered in lymph instead of 4,5% in treated rats. Although a low amount of lipids was concerned in this experiment, actidionecycloheximide and acetoxycycloheximide strongly inhibit intestinal absorption of oleic acid in lymph.

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Year:  1981        PMID: 6786779

Source DB:  PubMed          Journal:  C R Seances Acad Sci III        ISSN: 0249-6313


  1 in total

1.  Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats.

Authors:  Arik Dahan; Amnon Hoffman
Journal:  Pharm Res       Date:  2006-08-11       Impact factor: 4.200

  1 in total

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