Literature DB >> 6786344

Stimulation of prostaglandin cyclooxygenase and prostacyclin synthetase activities by estradiol in rat aortic smooth muscle cells.

W C Chang, J Nakao, H Orimo, S I Murota.   

Abstract

The effects of estradiol on the arachidonic acid pool and prostacyclin biosynthetic activity in rat aortic smooth muscle cells were studied. Estradiol has no significant effect on the distribution of [14C]arachidonic acid in cells with respect to prostacyclin production assay, the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and cellular phospholipase (or/and lipase) activities. However, estradiol significantly stimulates both prostaglandin cyclooxygenase and prostacyclin synthetase activities of cells, and induction of new protein biosynthesis is involved in the effect of estradiol on the stimulation of prostacyclin biosynthetic activity.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6786344

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Acute Coronary Syndromes: Molecular Basis for Cardiac Risk Factors.

Authors: 
Journal:  J Thromb Thrombolysis       Date:  1997       Impact factor: 2.300

Review 2.  Postmenopausal hormone therapy, SERMs, and coronary heart disease in women.

Authors:  N K Wenger; D Grady
Journal:  J Endocrinol Invest       Date:  1999-09       Impact factor: 4.256

3.  Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

Authors:  C R Rosenfeld; B E Cox; T Roy; R R Magness
Journal:  J Clin Invest       Date:  1996-11-01       Impact factor: 14.808

Review 4.  Estrogen effects in the heart.

Authors:  T Pelzer; A Shamim; L Neyses
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

5.  Sex differences of human cortical blood flow and energy metabolism.

Authors:  Joel Aanerud; Per Borghammer; Anders Rodell; Kristjana Y Jónsdottir; Albert Gjedde
Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

6.  In vitro prostacyclin production by ovine uterine and systemic arteries. Effects of angiotensin II.

Authors:  R R Magness; K Osei-Boaten; M D Mitchell; C R Rosenfeld
Journal:  J Clin Invest       Date:  1985-12       Impact factor: 14.808

7.  Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway.

Authors:  R H Karas; E A Gauer; H E Bieber; W E Baur; M E Mendelsohn
Journal:  J Clin Invest       Date:  1998-06-15       Impact factor: 14.808

8.  The Effect of Eqoul, a Metabolite of Isoflavone, on Endothelial Cell-independent Vasodilatation of Human Uterine Artery In Vitro.

Authors:  Jeong Yuen Kim; Moo Yeol Lee; Hyoung Moo Park
Journal:  J Bone Metab       Date:  2015-05-31
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.