Literature DB >> 6785816

Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients.

R Rimón, I Averbuch, P Rozick, L Fijman-Danilovich, T Kara, H Dasberg, R P Ebstein, R H Belmaker.   

Abstract

Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-nonresponsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.

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Year:  1981        PMID： 6785816     DOI： 10.1007/BF00429218

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  9 in total

1.  A radioreceptor assay for neuroleptic drugs in plasma.

Authors:  S R Lader
Journal:  J Immunoassay       Date:  1980

2.  Pharmacokinetic studies on haloperidol in man.

Authors:  A Forsman; R Ohman
Journal:  Curr Ther Res Clin Exp       Date:  1976-09

3.  High dosage haloperidol therapy in chronic schizophrenic patients: a double-blind study of clinical response, side effects, serum haloperidol, and serum prolactin.

Authors:  N Bjørndal; M Bjerre; J Gerlach; P Kristjansen; G Magelund; I H Oestrich; J Waehrens
Journal:  Psychopharmacology (Berl)       Date:  1980-01       Impact factor: 4.530

4.  Studies on serum protein binding of haloperidol.

Authors:  A Forsman; R Ohman
Journal:  Curr Ther Res Clin Exp       Date:  1977-02

5.  Blood levels of neuroleptic drugs in nonresponding chronic schizophrenic patients.

Authors:  R C Smith; J Crayton; H Dekirmenjian; D Klass; J M Davis
Journal:  Arch Gen Psychiatry       Date:  1979-05

6.  Neuroleptic drug levels and therapeutic response: preliminary observations with red blood cell bound butaperazine.

Authors:  D L Garver; H Dekirmenjian; J M Davis; R Casper; S Ericksen
Journal:  Am J Psychiatry       Date:  1977-03       Impact factor: 18.112

7.  Plasma levels of chlorpromazine in schizophrenia; a critical review of the literature.

Authors:  P R May; T Van Putten
Journal:  Arch Gen Psychiatry       Date:  1978-09

8.  Serum haloperidol determinations in psychiatric patients. Comparison of methods and correlation with serum prolactin level.

Authors:  R T Rubin; A Forsman; J Heykants; R Ohman; B Tower; M Michiels
Journal:  Arch Gen Psychiatry       Date:  1980-09

9.  Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia.

Authors:  L E Tune; I Creese; J R Depaulo; P R Slavney; J T Coyle; S H Snyder
Journal:  Am J Psychiatry       Date:  1980-02       Impact factor: 18.112
  9 in total
  10 in total

1.  Serum neuroleptic concentrations and clinical response: a radioreceptor assay investigation of acutely psychotic patients.

Authors:  L T Kucharski; P Alexander; L Tune; J Coyle
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

Review 2.  Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System.

Authors:  Nithya Srinivas; Kaitlyn Maffuid; Angela D M Kashuba
Journal:  Clin Pharmacokinet       Date:  2018-09       Impact factor: 6.447

3.  Human scalp hair as evidence of individual dosage history of haloperidol: method and retrospective study.

Authors:  T Uematsu; R Sato; K Suzuki; S Yamaguchi; M Nakashima
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 4.  The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia.

Authors:  S Ulrich; C Wurthmann; M Brosz; F P Meyer
Journal:  Clin Pharmacokinet       Date:  1998-03       Impact factor: 6.447

5.  Human scalp hair as evidence of individual dosage history of haloperidol: a possible linkage of haloperidol excretion into hair with hair pigment.

Authors:  T Uematsu; R Sato; O Fujimori; M Nakashima
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

6.  Antiemetic effect of haloperidol in the dog as related to plasma level and dose.

Authors:  C J Niemegeers; J J Heykants; P A Janssen
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

7.  Haloperidol plasma levels and clinical response in paranoid schizophrenics.

Authors:  P Linkowski; P Hubain; R von Frenckell; J Mendlewicz
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1984

8.  The measurement of haloperidol and reduced haloperidol in hair as an index of dosage history.

Authors:  H Matsuno; T Uematsu; M Nakashima
Journal:  Br J Clin Pharmacol       Date:  1990-02       Impact factor: 4.335

9.  Stability of serum neuroleptic and prolactin concentrations during short- and long-term treatment of schizophrenic patients.

Authors:  M L Rao; W A Brown
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 10.  Pharmacokinetics of haloperidol.

Authors:  J S Froemming; Y W Lam; M W Jann; C M Davis
Journal:  Clin Pharmacokinet       Date:  1989-12       Impact factor: 6.447
  10 in total

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