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Literature DB >> 6784897

Plasma levels and cardiovascular effect of nitroglycerin in pregnant sheep.

M de Rosayro, M L Nahrwold, A B Hill, A R Tait, M D Busch, M M Kirsh.

Abstract

The cardiovascular effects and blood levels of intravenous nitroglycerin in mother and foetus were studied in normotensive and hypertensive ewes. Although nitroglycerin produced a reduction in uterine blood flow following a decrease in blood pressure, there was little if any incidence of adverse effects in the foetus. Nitroglycerin was detected in all but two samples of foetal arterial blood but the foetal/maternal artery ratio was only 0.04. Nitroglycerin merits further evaluation for the treatment of acute hypertensive episodes in the preeclamptic patient.

Entities: Chemical Disease Species

Mesh：

Substances：
Nitroglycerin

Year: 1980 PMID： 6784897 DOI： 10.1007/BF03006886

Source DB: PubMed Journal: Can Anaesth Soc J ISSN： 0008-2856

11 in total

1. EFFECTS OF SYMPATHOMIMETIC DRUGS AND ANGIOTENSIN ON THE UTERINE VASCULAR BED.

Authors: F C GREISS
Journal: Obstet Gynecol Date: 1964-06 Impact factor: 7.661

2. Correspondence: Diazoxide in treatment of severe pre-eclampsia and hypertensive encephalopathy.

Authors: R P Perkins
Journal: Am J Obstet Gynecol Date: 1976-09-15 Impact factor: 8.661

3. Dynamics of uterine circulation in pregnant and nonpregnant sheep.

Authors: C Ladner; C R Brinkman; P Weston; N S Assali
Journal: Am J Physiol Date: 1970-01

4. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe.

Authors: D H Ralston; S M Shnider; A A DeLorimier
Journal: Anesthesiology Date: 1974-04 Impact factor: 7.892

5. Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation.

Authors: C Prys-Roberts; L T Greene; R Meloche; P Foëx
Journal: Br J Anaesth Date: 1971-06 Impact factor: 9.166

Plasma levels and cardiovascular effect of nitroglycerin in pregnant sheep.

1. EFFECTS OF SYMPATHOMIMETIC DRUGS AND ANGIOTENSIN ON THE UTERINE VASCULAR BED.

2. Correspondence: Diazoxide in treatment of severe pre-eclampsia and hypertensive encephalopathy.

3. Dynamics of uterine circulation in pregnant and nonpregnant sheep.

4. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe.

5. Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation.

6. Toxicity of sodium nitroprusside.

7. Organic nitrates: relationship between biotransformation and rational angina pectoris therapy.

8. Placental transfer of diazoxide and its hazardous effect on the newborn.

9. Nitroglycerin infusion during coronary-artery surgery.

10. Clinical evaluation of intravenous nitroglycerin for neurosurgery.

1. Antepartum uterine relaxation with nitroglycerin at caesarean delivery.