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Literature DB >> 6784676

Microbial transformations of 7,2-dimethylbenz[a]anthracene.

Abstract

Microbial transformations of 7,12-dimethylbenz[a]anthracene, a carcinogenic polycyclic aromatic hydrocarbon, in cultures of Pseudomonas aeruginosa and Penicillium notatum were studied by high performance liquid chromatographic separation of metabolic fractions followed by gas chromatographic-mass spectrometric analysis of the metabolites. Two methyl-hydroxylated metabolites were identified in each of the incubations. The metabolic activation of the polycyclic aromatic hydrocarbon suggests a possible involvement of microorganisms in environmental carcinogenesis.

Entities: Chemical Disease Species

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Year: 1981 PMID： 6784676 PMCID： PMC243787 DOI： 10.1128/aem.41.3.843-845.1981

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

12 in total

1. Microbial conversion of anthracycline antibiotics.

Authors: P F Wiley; V P Marshall
Journal: J Antibiot (Tokyo) Date: 1975-10 Impact factor: 2.649

2. Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

Authors: C HUGGINS; L C GRAND; F P BRILLANTES
Journal: Nature Date: 1961-01-21 Impact factor: 49.962

3. Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata.

Authors: R E Betts; D E Walters; J P Rosazza
Journal: J Med Chem Date: 1974-06 Impact factor: 7.446

4. Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations.

Authors: P Sims
Journal: Biochem Pharmacol Date: 1970-03 Impact factor: 5.858

5. Microbial transformations of natural antitumor agents. 2. Studies with d-tetrandrine and laudanosine.

Authors: P J Davis; J P Rosazza
Journal: J Org Chem Date: 1976-07-23 Impact factor: 4.354

6. Induction of adrenal damage and cancer with metabolites of 7,12-dimethylbenz(a)anthracene.

Authors: E Boyland; P Sims; C Huggins
Journal: Nature Date: 1965-08-21 Impact factor: 49.962

7. Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.

Authors: M W Chou; S K Yang
Journal: Proc Natl Acad Sci U S A Date: 1978-11 Impact factor: 11.205

8. Microbial models of mammalian metabolism O-demethylations of papaverine.

Authors: J P Rosazza; M Kammer; L Youel
Journal: Xenobiotica Date: 1977-03 Impact factor: 1.908

9. Oxidative metabolites of 7,12-dimethylbenz[a]anthracene. Further investigation of the K-region epoxide.

Authors: L K Wong; C L Wang; F B Daniel
Journal: Drug Metab Dispos Date: 1980 Jan-Feb Impact factor: 3.922

10. The induction of lung tumours by the injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into newborn suckling and young adult mice. A dose response study.

Authors: M A Walters
Journal: Br J Cancer Date: 1966-03 Impact factor: 7.640

5 in total

Microbial transformations of 7,2-dimethylbenz[a]anthracene.

1. Microbial conversion of anthracycline antibiotics.

2. Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

3. Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata.

4. Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations.

5. Microbial transformations of natural antitumor agents. 2. Studies with d-tetrandrine and laudanosine.

6. Induction of adrenal damage and cancer with metabolites of 7,12-dimethylbenz(a)anthracene.

7. Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.

8. Microbial models of mammalian metabolism O-demethylations of papaverine.

9. Oxidative metabolites of 7,12-dimethylbenz[a]anthracene. Further investigation of the K-region epoxide.

10. The induction of lung tumours by the injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into newborn suckling and young adult mice. A dose response study.

1. Regio- and stereoselective metabolism of 7,12-dimethylbenz[a]anthracene by Mycobacterium vanbaalenii PYR-1.

2. Metabolism of 7,12-dimethylbenz[a]anthracene by Cunninghamella elegans.

3. Regio- and stereo-selective metabolism of 4-methylbenz[a]anthracene by the fungus Cunninghamella elegans.

Review 4. Detoxification of polycyclic aromatic hydrocarbons by fungi.

5. Metabolism of 7-methylbenz[a]anthracene and 7-hydroxymethylbenz[a]anthracene by Cunninghamella elegans.