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Literature DB >> 6783018

Dissociation between free and bound phenytoin levels in presence of valproate sodium.

E A Rodin, G DeSousa, D Haidukewych, R Lodhi, R C Berchou.

Abstract

A dissociation of free vs bound phenytoin levels is frequently observed in the presence of therapeutic doses of valproate sodium. This leads at times to symptoms and signs of phenytoin intoxication despite "therapeutic" plasma levels. The importance of supplementing bound levels with free levels is stressed when combined therapy of this type is used in epileptic patients.

Entities: Chemical Disease Species

Mesh：

Substances：
Valproic Acid
Phenytoin

Year: 1981 PMID： 6783018 DOI： 10.1001/archneur.1981.00510040066011

Source DB: PubMed Journal: Arch Neurol ISSN： 0003-9942

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Cited

14 in total

Review 1. Protein binding drug displacement interactions fact or fiction?

Authors: J J MacKichan
Journal: Clin Pharmacokinet Date: 1989-02 Impact factor: 6.447

2. Interaction between valproic Acid and phenytoin.

Authors: R G Closson
Journal: West J Med Date: 1983-01

Review 3. Drug interactions that matter. A critical reappraisal.

Authors: G T McInnes; M J Brodie
Journal: Drugs Date: 1988-07 Impact factor: 9.546

Review 4. Clinical features and management of poisoning due to phenytoin.

Authors: J R Larsen; L S Larsen
Journal: Med Toxicol Adverse Drug Exp Date: 1989 Jul-Aug

5. An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis.

Authors: F Pisani; A Fazio; C Artesi; G Oteri; B Pisani; F Romano; E Perucca; R Di Perri
Journal: Ital J Neurol Sci Date: 1987-04

Dissociation between free and bound phenytoin levels in presence of valproate sodium.

Review 1. Protein binding drug displacement interactions fact or fiction?

2. Interaction between valproic Acid and phenytoin.

Review 3. Drug interactions that matter. A critical reappraisal.

Review 4. Clinical features and management of poisoning due to phenytoin.

5. An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis.

Review 6. Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations.

7. Free level monitoring of antiepileptic drugs. Clinical usefulness and case studies.

Review 8. Therapeutic drug concentration monitoring using saliva samples. Focus on anticonvulsants.

Review 9. Pharmacokinetic interactions with antiepileptic drugs.

Review 10. Drug interactions with valproic acid.