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Literature DB >> 6782551

Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymerase alpha by aphidicolin.

Abstract

On activated DNA aphidicolin competitively inhibits the incorporation of dCMP by both calf thymus DNA polymerase alpha A2 and C enzymes and inhibits the incorporation of the other three deoxynucleoside monophosphates apparently non-competitively. However, aphidicolin does not inhibit the incorporation of dAMP into poly(dT) . oligo(A)10 nor does it inhibit the incorporation of dGMP into poly(dC) . oligo(dG)10, but, it does competitively inhibit the incorporation of dTMP into poly(dA) . oligo(dT)10.

Entities: Chemical Species

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Year: 1981 PMID： 6782551 PMCID： PMC326675 DOI： 10.1093/nar/9.1.161

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

12 in total

1. Effect of aphidicolin on viral and human DNA polymerases.

Authors: G Pedrali-Noy; S Spadari
Journal: Biochem Biophys Res Commun Date: 1979-06-27 Impact factor: 3.575

2. Studies on the purification and properties of a 6.8-S DNA polymerase activity found in calf-thymus DNA polymerase-alpha fraction.

Authors: I P Hesslewood; A M Holmes; W F Wakeling; I R Johnston
Journal: Eur J Biochem Date: 1978-03

3. The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase alpha.

Authors: M Oguro; C Suzuki-Hori; H Nagano; Y Mano; S Ikegami
Journal: Eur J Biochem Date: 1979-07

4. The occurrence of multiple activities in the high-molecular-weight DNA polymerase fraction of mammalian tissues. A preliminary study of some of their properties.

Authors: A M Holmer; I P Hesslewood; I R Johnston
Journal: Eur J Biochem Date: 1974-04-16

5. Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha.

Authors: G E Wright; E F Baril; N C Brown
Journal: Nucleic Acids Res Date: 1980-01-11 Impact factor: 16.971

6. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha.

Authors: S Ikegami; T Taguchi; M Ohashi; M Oguro; H Nagano; Y Mano
Journal: Nature Date: 1978-10-05 Impact factor: 49.962

7. Further studies on partially purified calf thymus DNA polymerase a.

Authors: K McKune; A M Holmes
Journal: Nucleic Acids Res Date: 1979-07-25 Impact factor: 16.971

8. Studies on the processivity of highly purified calf thymus 8S and 7.3S DNA polymerase alpha.

Authors: K McKune; A M Holmes
Journal: Biochem Biophys Res Commun Date: 1979-10-12 Impact factor: 3.575

9. Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.

Authors: H Krokan; P Schaffer; M L DePamphilis
Journal: Biochemistry Date: 1979-10-02 Impact factor: 3.162

Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymerase alpha by aphidicolin.

1. Effect of aphidicolin on viral and human DNA polymerases.

2. Studies on the purification and properties of a 6.8-S DNA polymerase activity found in calf-thymus DNA polymerase-alpha fraction.

3. The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase alpha.

4. The occurrence of multiple activities in the high-molecular-weight DNA polymerase fraction of mammalian tissues. A preliminary study of some of their properties.

5. Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha.

6. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha.

7. Further studies on partially purified calf thymus DNA polymerase a.

8. Studies on the processivity of highly purified calf thymus 8S and 7.3S DNA polymerase alpha.

9. Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.

10. Differential inhibition of DNA polymerases of calf thymus by 9-beta-D-arabinofuranosyladenine-5'-triphosphate.

1. Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.

2. DNA polymerase requirements for parvovirus H-1 DNA replication in vitro.

3. DNA polymerase alpha and models for proofreading.

4. Aphidicolin inhibits DNA synthesis by DNA polymerase alpha and isolated nuclei by a similar mechanism.

5. Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.

Review 6. Enzymes involved in organellar DNA replication in photosynthetic eukaryotes.