Literature DB >> 6781982

Biochemical differences between products of the Adh locus in Drosophila.

J F McDonald, S M Anderson, M Santos.   

Abstract

An analysis of the molecular properties of the major alcohol dehydrogenase (E.C.1.1.1.1.) allozyme variants found segregating in natural populations of D. melanogaster is presented. Our results indicate: (1) ADH-S enzyme has generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype. The possible adaptive significance of these findings is discussed.

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Year:  1980        PMID： 6781982      PMCID： PMC1214263     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  17 in total

1.  Structural analysis of the ADHS electromorph of Drosophila melanogaster.

Authors:  T S Fletcher; F J Ayala; D R Thatcher; G K Chambers
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

2.  Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli.

Authors:  J IMSANDE
Journal:  J Biol Chem       Date:  1961-05       Impact factor: 5.157

3.  Alcohol dehydrogenase from Drosophila melanogaster.

Authors:  J I Elliott; J A Knopp
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

4.  Genetical variation for enzyme activity in a population of Drosophila melanogaster. IV. Analysis of alcohol dehydrogenase activity in chromosome substitution lines.

Authors:  B W Barnes; A J Birley
Journal:  Heredity (Edinb)       Date:  1978-02       Impact factor: 3.821

5.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

6.  The relative quantities and catalytic activities of enzymes produced by alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.

Authors:  T H Day; P C Hillier; B Clarke
Journal:  Biochem Genet       Date:  1974-02       Impact factor: 1.890

7.  Variation in ADH activity in class I and class II strains of Drosophila.

Authors:  N E Hewitt; S B Pipkin; N Williams; P K Chakrabartty
Journal:  J Hered       Date:  1974 May-Jun       Impact factor: 2.645

8.  Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster.

Authors:  J F McDonald; F J Ayala
Journal:  Genetics       Date:  1978-06       Impact factor: 4.562

9.  Genetic control of alcohol dehydrogenase levels in Drosophila.

Authors:  G Maroni
Journal:  Biochem Genet       Date:  1978-06       Impact factor: 1.890

10.  Dynamics of correlated genetic systems. IV. Multilocus effects of ethanol stress environments.

Authors:  D R Cavener; M T Clegg
Journal:  Genetics       Date:  1978-11       Impact factor: 4.562
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  30 in total

1.  The effect of temperature on biochemical and molecular properties of Drosophila alcohol dehydrogenase.

Authors:  K C McElfresh; J F McDonald
Journal:  Biochem Genet       Date:  1986-12       Impact factor: 1.890

2.  Estimating single gene effects on quantitative traits : 2. Statistical properties of five experimental methods.

Authors:  D G Gilbert
Journal:  Theor Appl Genet       Date:  1985-03       Impact factor: 5.699

3.  Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is associated with altered developmental and tissue-specific patterns of expression.

Authors:  D J Strand; J F McDonald
Journal:  Genetics       Date:  1989-04       Impact factor: 4.562

4.  The alcohol dehydrogenase alleloenzymes AdhS and AdhF from the fruitfly Drosophila melanogaster: an enzymatic rate assay to determine the active-site concentration.

Authors:  J O Winberg; R Hovik; J S McKinley-McKee
Journal:  Biochem Genet       Date:  1985-04       Impact factor: 1.890

5.  Larval behavioral response to environmental ethanol in relation to alcohol dehydrogenase activity level in Drosophila melanogaster.

Authors:  E Depiereux; N Hougouto; J Lechien; M Libion-Mannaert; M C Liétaert; E Feytmans; A Elens
Journal:  Behav Genet       Date:  1985-03       Impact factor: 2.805

6.  Properties of allelic variants of phosphoglucomutase from the sea anemone Metridium senile.

Authors:  R J Hoffmann
Journal:  Biochem Genet       Date:  1985-12       Impact factor: 1.890

7.  Copia is transcriptionally responsive to environmental stress.

Authors:  D J Strand; J F McDonald
Journal:  Nucleic Acids Res       Date:  1985-06-25       Impact factor: 16.971

8.  Alcohol dehydrogenase thermostability variants in Drosophila melanogaster: comparison of activity ratios and enzyme levels.

Authors:  B Sampsell; E Steward
Journal:  Biochem Genet       Date:  1983-12       Impact factor: 1.890

9.  The purification and biochemical properties of alcohol dehydrogenase--"fast (Chateau Douglas)" from Drosophila melanogaster.

Authors:  G K Chambers
Journal:  Biochem Genet       Date:  1984-06       Impact factor: 1.890

10.  Biochemical and molecular analysis of naturally occurring Adh variants in Drosophila melanogaster.

Authors:  S M Anderson; J F McDonald
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205
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