Literature DB >> 6781930

Effect of liposomes containing cholesterol on a hepatic cholesterol-7 a-hydroxylase and drug oxidation system.

G Deliconstantinos.   

Abstract

A statistically significant increase (p less than 0.01) in the activities of the microsomal enzymes cholesterol-7 a-hydroxylase (EC 1.14.13.17), biphenyl-4-hydroxylase, aniline hydroxylase, NADPH-cytochrome-c-reductase (EC 1.6.2.4) and p-nitroanisole-O-demethylase, was shown in cholesterol-loaded rat liver microsomes. The data indicate that profound functional changes are induced in membrane proteins by exogenous cholesterol.

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Year:  1981        PMID： 6781930     DOI： 10.1007/BF01965584

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

Review 1.  Phase transitions and fluidity characteristics of lipids and cell membranes.

Authors:  D Chapman
Journal:  Q Rev Biophys       Date:  1975-05       Impact factor: 5.318

2.  AN ADAPTIVELY STIMULATED O-DEMETHYLATING SYSTEM IN RAT LIVER MICROSOMES AND ITS KINETIC PROPERTIES.

Authors:  K J NETTER; G SEIDEL
Journal:  J Pharmacol Exp Ther       Date:  1964-10       Impact factor: 4.030

3.  Phosphorus assay in column chromatography.

Authors:  G R BARTLETT
Journal:  J Biol Chem       Date:  1959-03       Impact factor: 5.157

Review 4.  Regulation of allosteric membrane-bound enzymes through changes in membrane lipid compostition.

Authors:  R N Farías; B Bloj; R D Morero; F Siñeriz; R E Trucco
Journal:  Biochim Biophys Acta       Date:  1975-06-30

Review 5.  The function of sterols in membranes.

Authors:  R A Demel; B De Kruyff
Journal:  Biochim Biophys Acta       Date:  1976-10-26

6.  Incorporation of cis-dichlorobiscyclopentylamineplatinum[II] into liposomes enhances its uptake by ADJ/PC6A tumours implanted subcutaneously into mice [proceedings].

Authors:  G Deliconstantinos; G Gregoriadis; G Abel; M Jones; D Robertson
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

7.  Evidence for biochemically different types of vesicles in the hepatic microsomal fraction.

Authors:  Y Imai; A Ito; R Sato
Journal:  J Biochem       Date:  1966-10       Impact factor: 3.387

8.  The role of NADPH-cytochrome c reductase in microsomal hydroxylation reactions.

Authors:  R A Prough; M D Burke
Journal:  Arch Biochem Biophys       Date:  1975-09       Impact factor: 4.013

9.  Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells.

Authors:  G Gregoriadis; C Davis
Journal:  Biochem Biophys Res Commun       Date:  1979-08-28       Impact factor: 3.575

10.  Biphenyl hydroxylations and spectrally apparent interactions with liver microsomes from hamsters pre-treated with phenobarbitone and 3-methylcholanthrene.

Authors:  M D Burke; J W Bridges
Journal:  Xenobiotica       Date:  1975-06       Impact factor: 1.908
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  3 in total

1.  Incorporation of the antitumor alkaloid thaliblastine in liposomes enhances its cytotoxic activity in vitro.

Authors:  D K Todorov; G Deliconstantinos
Journal:  Experientia       Date:  1982-07-15

2.  Free cholesterol not carried by lipoproteins in human serum.

Authors:  G Deliconstantinos
Journal:  Experientia       Date:  1983-07-15

3.  Alterations in the activities of hepatic plasma-membrane and microsomal enzymes during liver regeneration.

Authors:  G Deliconstantinos; G Ramantanis
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857
  3 in total

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