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Literature DB >> 6781925

The structure and function of tRNA genes of higher eukaryotes.

Abstract

The most recent findings concerning the structure and function of tRNA genes of higher eukaryotes are discussed in an exemplary way. The tRNA genes of higher organisms are either dispersed or clustered at different sites of the genome. Clusters contain tRNA genes oriented in both directions and on both strands of the DNA with spacers of various length inbetween. Some genes contain intervening sequences close to the 3' side of the anticodon. The primary transcription product possesses a 5' leader and a 3' trailer sequence which are removed by several maturation steps in a strict temporal and spacial order. Internal transcription control regions (promotors) are located at the 5' and 3' ends of the mature tRNA coding section of the tRNA gene. External sequences modulating the efficiency of the expression are present at the immediate 5' ends of the genes. Transfer RNA genes are located nonrandomly in the nucleosomes.

Entities: Gene

Mesh：

Substances：
Nucleosomes
RNA, Transfer

Year: 1981 PMID： 6781925 DOI： 10.1007/BF01965537

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

41 in total

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Authors: R H Burdon; B T Martin; B M Lal
Journal: J Mol Biol Date: 1967-09-14 Impact factor: 5.469

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Journal: J Mol Biol Date: 1973-09-15 Impact factor: 5.469

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Authors: D C Tiemeier; S M Tilghman; F I Polsky; J G Seidman; A Leder; M H Edgell; P Leder
Journal: Cell Date: 1978-06 Impact factor: 41.582

4. A revolution in biology.

Authors: J Abelson
Journal: Science Date: 1980-09-19 Impact factor: 47.728

5. Evolution of a D. melanogaster glutamate tRNA gene cluster.

Authors: H A Hosbach; M Silberklang; B J McCarthy
Journal: Cell Date: 1980-08 Impact factor: 41.582

6. Analysis of a drosophila tRNA gene cluster.

Authors: B Hovemann; S Sharp; H Yamada; D Söll
Journal: Cell Date: 1980-04 Impact factor: 41.582

7. Dimeric tRNA precursors in yeast.

Authors: O Schmidt; J Mao; R Ogden; J Beckmann; H Sakano; J Abelson; D Söll
Journal: Nature Date: 1980-10-23 Impact factor: 49.962

8. Nucleotide sequence of genes coding for tRNAPhe and tRNATyr from a repeating unit of X. laevis DNA.

Authors: F Müller; S G Clarkson
Journal: Cell Date: 1980-02 Impact factor: 41.582

9. Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis.

Authors: A Kressmann; S G Clarkson; V Pirrotta; M L Birnstiel
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

10. The primary transcription product of a silkworm alanine tRNA gene: identification of in vitro sites of initiation, termination and processing.

Authors: O Hagenbüchle; D Larson; G I Hall; K U Sprague
Journal: Cell Date: 1979-12 Impact factor: 41.582

4 in total

1. Coadaptation of isoacceptor tRNA genes and codon usage bias for translation efficiency in Aedes aegypti and Anopheles gambiae.

Authors: S K Behura; D W Severson
Journal: Insect Mol Biol Date: 2010-10-29 Impact factor: 3.585