Literature DB >> 6781921

A possible method for improving the efficacy of dapsone.

K Prabhakaran, E B Harris, W F Kirchheimer.   

Abstract

The antileprosy drug dapsone is unable to penetrate intact Mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.

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Year:  1980        PMID： 6781921     DOI： 10.1007/BF01960091

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Use of 3,4-Dihydroxyphenylalanine Oxidation in the Identification of Mycobacterium leprae.

Authors:  K Prabhakaran; W F Kirchheimer
Journal:  J Bacteriol       Date:  1966-10       Impact factor: 3.490

2.  Lepromatoid lesion developed in nude mouse inoculated with Mycobacterium leprae--animal transmission of leprosy.

Authors:  K Kohsaka; T Mori; T Ito
Journal:  Repura       Date:  1976 Jul-Sep

3.  Rifampin-resistant leprosy.

Authors:  R R Jacobson; R C Hastings
Journal:  Lancet       Date:  1976-12-11       Impact factor: 79.321

4.  The nature of the phenolase enzyme in Mycobacterium leprae: structure-activity relationships of substrates and comparison with other copper proteins and enzymes.

Authors:  K Prabhakaran; E B Harris; W F Kirchheimer
Journal:  Microbios       Date:  1972

5.  Metabolic inhibitors of host-tissue origin in Mycobacterium leprae.

Authors:  K Prabhakaran; E B Harris; W F Kirchheimer
Journal:  Lepr India       Date:  1979-07

6.  The treatment of leprosy with the sulfones. I. Faget's original 22 patients. A thirty-year follow-up on sulfone therapy for leprosy.

Authors:  R R Jacobson; J R Trautman
Journal:  Int J Lepr Other Mycobact Dis       Date:  1971 Jul-Sep

7.  o-Diphenoloxidase of Mycobacterium leprae separated from infecected armadillo tissues.

Authors:  K Prabhakaran; E B Harris; W F Kirchheimer
Journal:  Infect Immun       Date:  1975-08       Impact factor: 3.441

8.  Dapsone-resistant Mycobacterium leprae in a patient receiving dapsone in low doses.

Authors:  S G Browne
Journal:  Int J Lepr Other Mycobact Dis       Date:  1969 Jul-Sep
  8 in total

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