Literature DB >> 6781614

Systemic lambda light-chain deposition in a patient with myeloma.

D Ganeval, L H Noël, D Droz, J Leibowitch.   

Abstract

Systemic lambda light-chain deposition occurred in a 73-year-old man with myeloma. An initial renal biopsy specimen showed the features of myeloma kidney. When he died 22 months later lambda light chains were detected by immunofluorescence in kidneys, liver, spleen, and heart. They were probably responsible for cardiac dysfunction and the fatal arrhythmia. It is suggested that in this patient deposition was due to a structural alteration of the light chains, possibly induced by cyclophosphamide.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6781614      PMCID： PMC1504513          DOI： 10.1136/bmj.282.6265.681

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  8 in total

1.  Variants of mouse myeloma cells that produce short immunoglobulin heavy chains.

Authors:  B K Birshtein; J L Preud'homme; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

Review 2.  Immunocytoma o' mice an' men.

Authors:  J R Hobbs
Journal:  Br Med J       Date:  1971-04-10

3.  Metabolism of Bence Jones proteins in multiple myeloma patients and in patients with renal disease.

Authors:  K Jensen
Journal:  Scand J Clin Lab Invest       Date:  1970-08       Impact factor: 1.713

Review 4.  Manifestations of systemic light chain deposition.

Authors:  R E Randall; W C Williamson; F Mullinax; M Y Tung; W J Still
Journal:  Am J Med       Date:  1976-02       Impact factor: 4.965

5.  Nonsecretory myeloma associated with nodular glomerulosclerosis.

Authors:  K Sølling; J Sølling; N O Jacobsen; O F Thomsen
Journal:  Acta Med Scand       Date:  1980

6.  An evaluation of diabetic and pseudodiabetic glomerulosclerosis.

Authors:  S Herf; S L Pohl; B Sturgill; W K Bolton
Journal:  Am J Med       Date:  1979-06       Impact factor: 4.965

7.  The role of the kidney in the catabolism of Bence Jones proteins and immunoglobulin fragments.

Authors:  R D Wochner; W Strober; T A Waldmann
Journal:  J Exp Med       Date:  1967-08-01       Impact factor: 14.307

8.  Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulin.

Authors:  J L Preud'Homme; L Morel-Maroger; J C Brouet; E Mihaesco; J P Mery; M Seligmann
Journal:  Clin Exp Immunol       Date:  1980-12       Impact factor: 4.330
  8 in total
  3 in total

1.  Renal and systemic kappa light chain deposits and their plasma cell origin identified by immunoelectron microscopy.

Authors:  M M Silver; S A Hearn; S Ritchie; R P Slinger; J A Sholdice; P S Cordy; A B Hodsman
Journal:  Am J Pathol       Date:  1986-01       Impact factor: 4.307

2.  Systemic lambda light-chain deposition presenting with predominant cardiac involvement.

Authors:  M J Garton; S Walton; S W Ewen
Journal:  Postgrad Med J       Date:  1993-07       Impact factor: 2.401

3.  Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome.

Authors:  Spyros Michopoulos; Kalliopi Petraki; Constantina Petraki; Meletios-Athanasios Dimopoulos
Journal:  Dig Dis Sci       Date:  2002-04       Impact factor: 3.199
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.