Literature DB >> 6780967

Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria.

D A Stumpf, J McAfee, J K Parks, L Eguren.   

Abstract

Propionate inhibits oxygen consumption by rat liver mitochondria when glutamate, alpha-ketaglutarate, and succinate are substrates. Carnitine prevents this effect. The pattern of inhibition of 14CO2 release from metabolic intermediates indicates citric acid cycle inhibition between succinate:coenzyme A (CoA) ligase (GDP) and malate dehydrogenase. Propionyl CoA is synthesized from propionate in mitochondria. Propionyl CoA is a potent inhibitor of succinate:CoA ligase with positive cooperativity and half half-maximal inhibition at 2 X 10(-4) M propionyl CoA.

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Year:  1980        PMID： 6780967     DOI： 10.1203/00006450-198010000-00008

Source DB:  PubMed          Journal:  Pediatr Res        ISSN： 0031-3998            Impact factor:   3.756


  22 in total

Review 1.  Propionyl-L-carnitine: biochemical significance and possible role in cardiac metabolism.

Authors:  N Siliprandi; F Di Lisa; R Menabò
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

2.  Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.

Authors:  Christos Chinopoulos; Akos A Gerencser; Miklos Mandi; Katalin Mathe; Beata Töröcsik; Judit Doczi; Lilla Turiak; Gergely Kiss; Csaba Konràd; Szilvia Vajda; Viktoria Vereczki; Richard J Oh; Vera Adam-Vizi
Journal:  FASEB J       Date:  2010-03-05       Impact factor: 5.191

Review 3.  L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain.

Authors:  Gustavo C Ferreira; Mary C McKenna
Journal:  Neurochem Res       Date:  2017-05-16       Impact factor: 3.996

4.  Clinical and biochemical findings on a child with multiple biotin-responsive carboxylase deficiencies.

Authors:  K Narisawa; N Arai; Y Igarashi; T Satoh; K Tada; Y Hirooka
Journal:  J Inherit Metab Dis       Date:  1982       Impact factor: 4.982

5.  Carnitine metabolism in the vitamin B-12-deficient rat.

Authors:  E P Brass; S P Stabler
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

6.  Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria.

Authors:  Parith Wongkittichote; Gary Cunningham; Marshall L Summar; Elena Pumbo; Patrick Forny; Matthias R Baumgartner; Kimberly A Chapman
Journal:  Mol Genet Metab       Date:  2019-10-17       Impact factor: 4.797

7.  Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes.

Authors:  E P Brass; P V Fennessey; L V Miller
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

8.  Effects of propionate on mechanical and metabolic performance in aerobic rat hearts.

Authors:  H Bolukoglu; S H Nellis; A J Liedtke
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

9.  L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia.

Authors:  C R Roe; D S Millington; D A Maltby; T P Bohan; C L Hoppel
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

10.  Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.

Authors:  Shruti Sharma; Neetu Sud; Dean A Wiseman; A Lee Carter; Sanjiv Kumar; Yali Hou; Thomas Rau; Jason Wilham; Cynthia Harmon; Peter Oishi; Jeffrey R Fineman; Stephen M Black
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2007-11-16       Impact factor: 5.464
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