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Literature DB >> 6779336

Biphasic effects of a potent enkephalin analogue (D-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice.

Abstract

The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3-10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.

Entities: Chemical Disease Gene Species

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Year: 1980 PMID： 6779336 DOI： 10.1007/bf00433065

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

13 in total

1. A simple method for producing tolerance to dihydromorphinone in mice.

Authors: L SHUSTER; R V HANNAM; W E BOYLE
Journal: J Pharmacol Exp Ther Date: 1963-05 Impact factor: 4.030

2. (D-met2, pro5)-enkephalinamide: a potent morphine-like analgesic.

Authors: J I Székely; A Z Rónai; Z Dunai-Kovács; E Miglécz; I Berzétri; S Bajusz; L Gráf
Journal: Eur J Pharmacol Date: 1977-06-01 Impact factor: 4.432

3. Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat.

Authors: T Oka; E Hosoya
Journal: Psychopharmacology (Berl) Date: 1976-06-23 Impact factor: 4.530

Review 4. Endogenous peptides and analgesia.

Authors: L Terenius
Journal: Annu Rev Pharmacol Toxicol Date: 1978 Impact factor: 13.820

4. Relationship of the Chemokine, CXCL12, to Effects of Dietary Fat on Feeding-Related Behaviors and Hypothalamic Neuropeptide Systems.

Authors: Kinning Poon; Jessica R Barson; Hui T Ho; Sarah F Leibowitz
Journal: Front Behav Neurosci Date: 2016-03-21 Impact factor: 3.558

4 in total

Biphasic effects of a potent enkephalin analogue (D-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice.

1. A simple method for producing tolerance to dihydromorphinone in mice.

2. (D-met2, pro5)-enkephalinamide: a potent morphine-like analgesic.

3. Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat.

Review 4. Endogenous peptides and analgesia.

5. Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse.

6. Effects of narcotic analgesics upon the locomotor activity and brain catecholamine content of the mouse.

7. A superactive antinociceptive pentapeptide, (D-Met2, Pro5)-enkephalinamide.

8. Behavioral effects of low and high acute doses of morphine in solitary mice.

9. In vivo antagonism by naloxone of morphine, beta-endorphin and a synthetic enkephalin analog.

10. Antagonism by physostigmine of the "running fit" caused by levorphanol, a morphine congener, in mice.

1. The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptors.

2. Differential Effects of a Novel Opioid Ligand UTA1003 on Antinociceptive Tolerance and Motor Behaviour.

3. Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors.

4. Relationship of the Chemokine, CXCL12, to Effects of Dietary Fat on Feeding-Related Behaviors and Hypothalamic Neuropeptide Systems.