Literature DB >> 6779322

Effects of kainic acid on body temperature of rats: role of catecholaminergic and serotonergic systems.

L Turski, Z Kleinrok.   

Abstract

Intraventricular (IV) administration of doses of 0.1 microgram kainic acid caused diphasic effects on the body temperature of rats--initially hypothermia, rapidly followed by hyperthermia. Pretreatment of rats with 6-OHDA effectively blocked the hypothermic and significantly increased the hyperthermic effects of kainic acid. The hyperthermic effect of kainic acid was reversed in the 5,6-DHT- and dorsal raphe-lesioned rats. However, the electrolytic lesion of the medial raphe nucleus did not cause any changes in the thermic activity of kainic acid. The thermic effects of kainic acid injected IV appear to be dependent on the balance between serotonergic and catecholaminergic influences on central thermoregulation.

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Year:  1980        PMID： 6779322     DOI： 10.1007/bf00433249

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  16 in total

1.  Effects of l-glutamate and related amino acids upon the release of [3H]dopamine from rat striatal slices.

Authors:  P J Roberts; N A Sharif
Journal:  Brain Res       Date:  1978-11-24       Impact factor: 3.252

2.  Effects of reserpine, para-chlorophenylalanine, 5,6-dihydroxytryptamine and fludiazepam on the head twitches induced by 5-hydroxytryptamine or 5-methoxytryptamine in mice.

Authors:  M Nakamura; H Fukushima
Journal:  J Pharm Pharmacol       Date:  1978-04       Impact factor: 3.765

3.  Possible involvement of 5-hydroxytryptamine in dopamine-receptor-mediated hypothermia in the rat.

Authors:  B Cox; T F Lee
Journal:  J Pharm Pharmacol       Date:  1979-05       Impact factor: 3.765

4.  Changes in striatal specific 3-H-atropine binding after unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurones.

Authors:  G Kato; S Carson; M L Kemel; J Glowinski; M F Giorguieff
Journal:  Life Sci       Date:  1978-05-08       Impact factor: 5.037

5.  Functional regeneration of 5-hydroxytryptamine nerve terminals in the rat spinal cord following 5, 6-dihydroxytryptamine induced degeneration.

Authors:  L G Nygren; K Fuxe; G Jonsson; L Olson
Journal:  Brain Res       Date:  1974-10-04       Impact factor: 3.252

6.  6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

Authors:  U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1968-12       Impact factor: 4.432

7.  Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

Authors:  G R Breese; T D Traylor
Journal:  J Pharmacol Exp Ther       Date:  1970-09       Impact factor: 4.030

8.  Kainic acid-induced wet dog shakes in rats. The relation to central neurotransmitters.

Authors:  Z Kleinrok; L Turski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

9.  p-Chloroamphetamine-induced hyperthermia pharmacologically distinct from fenfluramine-induced hyperthermia.

Authors:  R M Quock; B G Weick
Journal:  J Pharm Pharmacol       Date:  1979-01       Impact factor: 3.765

10.  Hypothermic effects of apomorphine homologues in mice.

Authors:  M K Menon; W G Clark; J G Cannon
Journal:  J Pharm Pharmacol       Date:  1979-05       Impact factor: 3.765
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  2 in total

1.  ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma.

Authors:  L Turski; A Huth; M Sheardown; F McDonald; R Neuhaus; H H Schneider; U Dirnagl; F Wiegand; P Jacobsen; E Ottow
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

2.  Effects of morphine and nalorphine on kainic acid-induced hypothermia in rats.

Authors:  L Turski; W Turski; S J Czuczwar; Z Kleinrok
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
  2 in total

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