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Literature DB >> 6778955

Respiratory effects of gamma-hydroxybutyric acid in anesthetized rats.

Abstract

Rats lightly anesthetized with halothane were treated with graded intraperitoneal doses of gamma-hydroxybutyric acid (GHBA), a GABA analogue. The drug induced a dose dependent decrease in minute ventilation, mainly due to reduced respiratory frequency. A reduced pH in arterial blood was recorded. GHBA also blunted or abolished the respiratory response to CO2 exposure in a dose-related way. Picrotoxin (0.25, 0.5 or 1.0 mg/kg intravenously), a presumed GABA antagonist did not significantly change the respiratory pattern when given alone but clearly antagonized the GHBA-induced respiratory depression. It is concluded that GABA-ergic mechanisms are involved in central respiratory control.

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Year: 1980 PMID： 6778955 DOI： 10.1007/bf01245223

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

13 in total

1. gamma Aminobutyric acid; circulatory and respiratory effects in different species; re-investigation of the anti-strychnine action in mice.

Authors: K A ELLIOTT; F HOBBIGER
Journal: J Physiol Date: 1959-04-23 Impact factor: 5.182

Respiratory effects of gamma-hydroxybutyric acid in anesthetized rats.

1. gamma Aminobutyric acid; circulatory and respiratory effects in different species; re-investigation of the anti-strychnine action in mice.

2. The effect of intracerebroventricularly administered GABA on brain monoamine metabolism.

3. Dihydropicrotoxinin binding sites in rat brain: comparison to GABA receptors.

4. The influence of increased brain 5-hydroxytryptamine upon the respiratory activity of cats.

5. Ventilatory response to alterations of H+ ion concentration in small areas of the ventral medullary surface.

6. Conversion in vivo of gamma-aminobutyric to gamma-hydroxybutyric acid in the rat.

7. Pharmacological studies on a possible role of central noradrenaline neurons in respiratory control.

8. Dopaminergic interaction with the respiratory control system in the rat.

9. Transient apnoea after systemic injection of GABA in the rat.

10. Evidence that respiratory depression by serotonin agonists may be exerted in the central nervous system.

1. Central respiratory and cardiovascular effects in the rat of some putative neurotransmitter amino acids.

2. GABA-ergic mechanisms in central respiratory control in the anesthetized rat.