Literature DB >> 6777907

Effects of acrylonitrile on rat liver cytochrome P-450, benzo(a)pyrene metabolism and serum hormone levels.

O G Nilsen, R Toftgard, P Eneroth.   

Abstract

Intraperitoneal injections of acrylonitrile (AN), 33 mg/kg, into male rats daily for 3 consecutive days resulted in a 20% decrease in the liver microsomal content of cytochrome P-450. The in vitro formation of 9-hydroxy and 9,10-dihydrodiol metabolites of benzo(a)pyrene in liver microsomes was inhibited. Serum corticosterone levels were markedly decreased (30% of th values for control animals) demonstrating a disturbed pituitary-adrenal axis. A central effect of AN is supported by the finding that prolactin concentrations fell by approximately 60% in exposed animals. AN also induced a doubling FSH levels, whereas LH concentrations were the same as in the control animals. These results suggest an impaired spermatogenesis in the exposed animals.

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Year:  1980        PMID： 6777907     DOI： 10.1016/0378-4274(80)90113-7

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  9 in total

1.  Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection.

Authors:  K Fuxe; A M Janson; A Jansson; K Andersson; P Eneroth; L F Agnati
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

2.  Effects of withdrawal from chronic exposure to cigarette smoke on hypothalamic and preoptic catecholamine nerve terminal systems and on the secretion of pituitary hormones in the male rat.

Authors:  K Andersson; K Fuxe; P Eneroth; A Jansson; A Härfstrand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

3.  Effects of acute intermittent exposure to cigarette smoke on hypothalamic and preoptic catecholamine nerve terminal systems and on neuroendocrine function in the diestrous rat.

Authors:  K Andersson; P Eneroth; K Fuxe; A Härfstrand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

4.  Changes in pituitary-adrenal activity affect the apomorphine- and cholecystokinin-8-induced changes in striatal dopamine release using microdialysis.

Authors:  S Tanganelli; K Fuxe; G von Euler; P Eneroth; L F Agnati; U Ungerstedt
Journal:  J Neural Transm Gen Sect       Date:  1990

5.  Interactions of nicotine and pentobarbitone in the regulation of telencephalic and hypothalamic catecholamine levels and turnover and of adenohypophyseal hormone secretion in the normal male rat.

Authors:  K Andersson; K Fuxe; P Eneroth; L F Agnati; J A Gustafsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-12       Impact factor: 3.000

6.  Effects of acute continuous exposure of the rat to cigarette smoke on amine levels and utilization in discrete hypothalamic catecholamine nerve terminal systems and on neuroendocrine function.

Authors:  K Andersson; K Fuxe; P Eneroth; L F Agnati; A Härfstrand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

7.  Chronic immobilization stress: evidence for decreases of 5-hydroxy-tryptamine immunoreactivity and for increases of glucocorticoid receptor immunoreactivity in various brain regions of the male rat.

Authors:  I Kitayama; A Cintra; A M Janson; K Fuxe; L F Agnati; P Eneroth; M Aronsson; A Härfstrand; H W Steinbush; T J Visser
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

8.  Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain. Evidence for selective increases of glucocorticoid receptor immunoreactivity in the locus coeruleus and in 5-hydroxytryptamine nerve cell groups of the rostral ventromedial medulla.

Authors:  I Kitayama; A M Janson; A Cintra; K Fuxe; L F Agnati; S O Ogren; A Härfstrand; P Eneroth; J A Gustafsson
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

9.  Effect of acrylonitrile on the rat pituitary: enlargement of Golgi region in prolactin cells, crinophagy in prolactin cells and growth hormone cells.

Authors:  K Kamijo; K Kovacs; S Szabo; J N Bollinger-Gruber; S Reichlin
Journal:  Br J Exp Pathol       Date:  1986-06
  9 in total

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