The new variant carbonic anhydrase in the Japanese: CAINagasaki 1(76 Arg replaced by Gln) and CAIHiroshima 2.

Hemolysates obtained from 4,919 residents of Hiroshima and 4,131 residents of Nagasaki for a total of 9,050 were examined for carbonic anhydrase I (CAI) using vertical starch gel electrophoresis. Eight inherited variants of carbonic anhydrase I, designated CAIHiroshima 1 (CAIHIR 1), were detected and two new fast variants of CAI were detected in one Nagasaki resident and in one Hiroshima resident. These fast variants were designated CAINagasaki 1 (CAINGS 1) and CAI Hiroshima 2 (CAIHIR 2). The isoelectric point of CAINGS 1 was 5.95 and that of CAIHIR 2 was 6.20.