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Literature DB >> 6776558

Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.

R A Glennon, R Young, J A Rosecrans, M J Kallman.

Abstract

A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).

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Year: 1980 PMID： 6776558 DOI： 10.1007/bf00432133

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

13 in total

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Authors: R G Browne; B T Ho
Journal: Pharmacol Biochem Behav Date: 1975 May-Jun Impact factor: 3.533

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Authors: R A Glennon; S M Liebowitz; E C Mack
Journal: J Med Chem Date: 1978-08 Impact factor: 7.446

3. Hallucinogens as a discriminative stimuli: generalization of DOM to a 5-methoxy-N, N-dimethyltryptamine stimulus.

Authors: R A Glennon; J A Rosecrans; R Young; J Gaines
Journal: Life Sci Date: 1979-03-12 Impact factor: 5.037

4. Blockade of the stimulus properties of mescaline by a serotonin antagonist.

Authors: J C Winter
Journal: Arch Int Pharmacodyn Ther Date: 1975-04

5. Stimulus properties of phenethylamine hallucinogens and lysergic acid diethylamide: the role of 5-hydroxytryptamine.

Authors: J C Winter
Journal: J Pharmacol Exp Ther Date: 1978-02 Impact factor: 4.030

6. The effect of chirality on serotonin receptor affinity.

Authors: R A Glennon
Journal: Life Sci Date: 1979-04-16 Impact factor: 5.037

7. The discriminative stimulus properties of LSD: mechanisms of action.

Authors: D M Kuhn; F J White; J B Appel
Journal: Neuropharmacology Date: 1978 Apr-May Impact factor: 5.250

8. Discriminative stimulus properties of mescaline: mescaline or metabolite?

Authors: R G Browne; B T Ho
Journal: Pharmacol Biochem Behav Date: 1975 Jan-Feb Impact factor: 3.533

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Authors: D E Nichols; C F Barfknecht; J P Long; R T Standridge; H G Howell; R A Partyka; D C Dyer
Journal: J Med Chem Date: 1974-02 Impact factor: 7.446

10. A sensitive method for the assay of 5-hydroxytryptamine.

Authors: J R VANE
Journal: Br J Pharmacol Chemother Date: 1957-09

13 in total

1. The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats.

Authors: Kirsten Krebs-Thomson; Erbert M Ruiz; Virginia Masten; Mahalah Buell; Mark A Geyer
Journal: Psychopharmacology (Berl) Date: 2006-09-30 Impact factor: 4.530

2. Psilocybin as a discriminative stimulus: lack of specificity in an animal behavior model for 'hallucinogens'.

Authors: J Koerner; J B Appel
Journal: Psychopharmacology (Berl) Date: 1982 Impact factor: 4.530

3. Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs.

Authors: Landon M Klein; Nicholas V Cozzi; Paul F Daley; Simon D Brandt; Adam L Halberstadt
Journal: Neuropharmacology Date: 2018-02-27 Impact factor: 5.250

4. Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression.

Authors: Lindsay P Cameron; Charlie J Benson; Lee E Dunlap; David E Olson
Journal: ACS Chem Neurosci Date: 2018-04-24 Impact factor: 4.418

5. Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats.

Authors: Michael B Gatch; Margaret A Rutledge; Theresa Carbonaro; Michael J Forster
Journal: Psychopharmacology (Berl) Date: 2009-03-14 Impact factor: 4.530

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Authors: R Young; J A Rosecrans; R A Glennon
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530

7. Discriminative stimulus properties of arecoline: a new approach for studying central muscarinic receptors.

Authors: L T Meltzer; J A Rosecrans
Journal: Psychopharmacology (Berl) Date: 1981 Impact factor: 4.530

8. Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.

Authors: D G Spencer; T Glaser; J Traber
Journal: Psychopharmacology (Berl) Date: 1987 Impact factor: 4.530

9. Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy.

Authors: Barbara A Bricker; Kwame Peprah; Hye J Kang; S Y Ablordeppey
Journal: Pharmacol Biochem Behav Date: 2019-02-12 Impact factor: 3.533

10. Chemoenzymatic Synthesis of 5-Methylpsilocybin: A Tryptamine with Potential Psychedelic Activity.

Authors: Janis Fricke; Alexander M Sherwood; Adam L Halberstadt; Robert B Kargbo; Dirk Hoffmeister
Journal: J Nat Prod Date: 2021-03-05 Impact factor: 4.803