Literature DB >> 6776411

Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.

W Altenburger, M Steinmetz, H G Zachau.   

Abstract

Leader, variable (V) and joining (J) gene segments, and adjacent regions of two rearranged alleles of the same kappa-chain producing mouse myeloma, comprising approximately 3,200 base pairs, have been sequenced. Sequence comparisons are reported. V-J joining in one of the alleles leads to a reading frame with a stop codon within the J-gene segments. Allelic exclusion is apparently realized in this tumour through the formation of such a non-functional allele.

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Year:  1980        PMID： 6776411     DOI： 10.1038/287603a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  31 in total

1.  Peritoneal B cells regulate the numbers of allotype-matched pre-B and B cells in bone marrow.

Authors:  M A Marcos; A Sundblad; E Malenchère; A Coutinho
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

2.  Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site.

Authors:  M R Pelletier; E N Hatada; G Scholz; C Scheidereit
Journal:  Nucleic Acids Res       Date:  1997-10-15       Impact factor: 16.971

3.  Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement.

Authors:  R M Feddersen; B G Van Ness
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

4.  Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation.

Authors:  D E Kelley; L M Wiedemann; A C Pittet; S Strauss; K J Nelson; J Davis; B Van Ness; R P Perry
Journal:  Mol Cell Biol       Date:  1985-07       Impact factor: 4.272

5.  Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment.

Authors:  J M Leiden; D P Dialynas; A D Duby; C Murre; J Seidman; J L Strominger
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

6.  Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes.

Authors:  F G Falkner; R Mocikat; H G Zachau
Journal:  Nucleic Acids Res       Date:  1986-11-25       Impact factor: 16.971

7.  An ACCC-containing protein-binding sequence in the neighbourhood of the decanucleotide recognition site of the immunoglobulin gene promoter.

Authors:  R Mocikat; G J Pruijn; P C van der Vliet; H G Zachau
Journal:  Nucleic Acids Res       Date:  1988-05-11       Impact factor: 16.971

8.  RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.

Authors:  N Hozumi; G E Wu; H Murialdo; L Roberts; D Vetter; W L Fife; M Whiteley; P Sadowski
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

9.  Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions.

Authors:  R Mocikat; F G Falkner; R Mertz; H G Zachau
Journal:  Nucleic Acids Res       Date:  1986-11-25       Impact factor: 16.971

10.  Differences in the nuclease sensitivity between the two alleles of the immunoglobulin kappa light chain genes in mouse liver and myeloma nuclei.

Authors:  W O Weischet; B O Glotov; H Schnell; H G Zachau
Journal:  Nucleic Acids Res       Date:  1982-06-25       Impact factor: 16.971
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