Literature DB >> 6775793

Influence of a diphosphonate on the cellular aspect of young bone tissue.

C M Plasmans, P H Jap, W Kuijpers, T J Slooff.   

Abstract

Stimulated by the rather sparse information in the literature on cellular changes induced by EHDP, we carried out electron microscopic investigations on young bone tissue and on de novo bone formation. Cellular changes could be observed during continuous administration of EHDP. The osteoblasts demonstrated temporary storing of crystalloid structures in the mitochondria, and atypical osteocytes showed persistent changes indicative of hyperactivity. The osteoclasts exhibited varying ultrastructural features with respect to the number and appearance of nuclei, Golgi, RER, and lysosomes. These changes under the influence of EHDP could be an indication of altered activity of the osteoclast. The possible interference of EHDP with bone cell metabolism is discussed.

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Year:  1980        PMID： 6775793     DOI： 10.1007/bf02408548

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  27 in total

1.  The alteration of osteoclast morphology by diphosphonates in bone organ culture.

Authors:  E J Rowe; E Hausmann
Journal:  Calcif Tissue Res       Date:  1976-04-13

2.  The effect of two diphosphonates on the handling of calcium by rat kidney mitochondria in vitro.

Authors:  D F Guilland; J D Sallis; H Fleisch
Journal:  Calcif Tissue Res       Date:  1974

3.  The bone induction principle.

Authors:  M R Urist; B F Silverman; K Büring; F L Dubuc; J M Rosenberg
Journal:  Clin Orthop Relat Res       Date:  1967 Jul-Aug       Impact factor: 4.176

4.  Effect of diphosphonates and calcitonin on the chemistry and quantitative histology of rat bone.

Authors:  R G Russell; A M Kislig; P A Casey; H Fleisch; J Thornton; R Schenk; D A Williams
Journal:  Calcif Tissue Res       Date:  1973-03-12

5.  Effect of disodium ethane-1-hydroxy-1, 1-diphosphonate on bone formation.

Authors:  W R King; M D Francis; W R Michael
Journal:  Clin Orthop Relat Res       Date:  1971       Impact factor: 4.176

6.  Osteogenesis in the interior of intramuscular implants of decalcified bone matrix.

Authors:  K A Van de Putte; M R Urist
Journal:  Clin Orthop Relat Res       Date:  1965 Nov-Dec       Impact factor: 4.176

7.  Alkaline phosphatase and failure of calcification under the influence of a diphosphonate.

Authors:  B S Strates; H E Firschein; M R Urist
Journal:  Biochim Biophys Acta       Date:  1971-07-20

8.  The effects of ethylene-1-hydroxy-1, 1-diphosphonate on cellular transformation and organic matrix of the epiphyseal growth plate of the rat--a light microscopic and ultrastructural study.

Authors:  A Larsson; S E Larsson
Journal:  Acta Pathol Microbiol Scand A       Date:  1978-05

9.  Light microscopic and ultrastructural observations on the short-term effects of ethylene-1-hydroxy-1, 1-diphosphonate (EHDP) on rat tibia epiphysis.

Authors:  A Larsson; S E Larsson
Journal:  Acta Pathol Microbiol Scand A       Date:  1976-01

10.  The comparative effects of dichloromethylene diphosphonate (C12MDP) and ethane-1-hydroxy-1,1-diphosphonate (EHDP) on growth and modeling of the rat tibia.

Authors:  S C Miller; W S Jee
Journal:  Calcif Tissue Res       Date:  1977-10-20
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  16 in total

Review 1.  Bisphosphonates: mechanisms of action.

Authors:  G A Rodan; H A Fleisch
Journal:  J Clin Invest       Date:  1996-06-15       Impact factor: 14.808

2.  Osteomalacia in Paget's disease treated with short term, high dose sodium etidronate.

Authors:  C J Gibbs; J E Aaron; M Peacock
Journal:  Br Med J (Clin Res Ed)       Date:  1986-05-10

3.  Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

Authors:  M Sato; W Grasser; N Endo; R Akins; H Simmons; D D Thompson; E Golub; G A Rodan
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

4.  Effect of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) and dichloromethylidene-bisphosphonate (Cl2MBP) on the structure of the organic matrix of heterotopically induced bone tissue.

Authors:  K Ostrowski; A Wojtowicz; A Dziedzic-Goclawska; M Rozycka
Journal:  Histochemistry       Date:  1988

5.  Low concentrations of zoledronic acid are better at regulating bone formation and repair.

Authors:  Xiaomeng Yang; Yanqin Lu; Zhiliang Li; Yanzhou Wang; Fei Zhao; Jinxiang Han
Journal:  Intractable Rare Dis Res       Date:  2013-02

6.  Osteoclast abnormalities in idiopathic osteopetrosis. Reference to the ultrastructural histochemistry study.

Authors:  P van Tran; A Dryll; J Lansaman; B Naveau; R Treve; L Miravet; A Ryckewaert
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1985

7.  Effect of sodium etidronate and phenytoin of Pagetic bone.

Authors:  H M Perry; L V Avioli
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

8.  Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders.

Authors:  Luigi Sinigaglia; Massimo Varenna; Silvia Casari
Journal:  Clin Cases Miner Bone Metab       Date:  2007-01

9.  Alendronate enhances osteogenic differentiation of bone marrow stromal cells: a preliminary study.

Authors:  Hyung Keun Kim; Ji Hyun Kim; Azlina Amir Abbas; Taek Rim Yoon
Journal:  Clin Orthop Relat Res       Date:  2008-07-30       Impact factor: 4.176

10.  Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma.

Authors:  F Wingen; H Sterz; H Blum; H Möller; W Pittermann; B L Pool; H J Sinn; H Spring; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553
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