Literature DB >> 6775788

Decreased breaking strength of diabetic rat bone and its improvement by insulin treatment.

P K Dixit, R A Ekstrom.   

Abstract

A simple instrument is described which measures the breaking strength of rat bones. The apparatus yields reproducible results and is suitable for use in measuring the strength of bones from both large and small animals. Diabetic rat femurs were more fragile and required less force to break in contrast to those from diabetic rats treated with insulin or normal rats. Daily insulin treatment significantly improved the bone cortical thickness and enhanced their capacity to withstand pressure, although these did not reach the level of the normal controls. The amount of force required to break the bone appears to be related to its cortical thickness and mass.

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Year:  1980        PMID： 6775788     DOI： 10.1007/bf02408541

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  10 in total

1.  Effect of insulin on the incorporation of citrate and calcium into the bones of alloxan-diabetic rats.

Authors:  P K Dixit; A M Stern
Journal:  Calcif Tissue Int       Date:  1979-07-03       Impact factor: 4.333

2.  THE INFLUENCE OF CORTISONE ON THE HEALING OF EXPERIMENTAL FRACTURES IN RATS.

Authors:  R WEISS; M ICKOWICZ
Journal:  Acta Anat (Basel)       Date:  1964

3.  AN APPARATUS FOR DETERMINATION OF BREAKING-STRENGTH OF SMALL RODENTS BONES.

Authors:  W J FELTS
Journal:  Anat Rec       Date:  1964-01

4.  The strength and elasticity of bone in rats on a rachitogenic diet.

Authors:  J B D WEIR; G H BELL; J W CHAMBERS
Journal:  J Bone Joint Surg Br       Date:  1949-08

5.  Osteoporosis and diabetes mellitus; report of a case.

Authors:  P W BERNEY
Journal:  J Iowa State Med Soc       Date:  1952-01

6.  Inhibition of bone resorption by acetazolamide in the rat.

Authors:  L C Waite; W A Volkert; A D Kenny
Journal:  Endocrinology       Date:  1970-12       Impact factor: 4.736

7.  Mechanical strength and mineral content of bone from rats fed acetazolamide.

Authors:  I Wolinsky; A D Kenny
Journal:  Calcif Tissue Res       Date:  1974

8.  Prevalence of diabetes mellitus in Jerusalem; its association with presenile osteoporosis.

Authors:  J Menczel; M Makin; G Robin; I Jaye; E Naor
Journal:  Isr J Med Sci       Date:  1972-06

9.  Carbonic anhydrase inhibitors, parathyroid hormone and calcium metabolism.

Authors:  L C Waite
Journal:  Endocrinology       Date:  1972-11       Impact factor: 4.736

10.  Breaking strength of chick bones as an indication of dietary calcium and phosphorus adequacy.

Authors:  L O Rowland; R H Harms; H R Wilson; I J Ross; J L Fry
Journal:  Proc Soc Exp Biol Med       Date:  1967-11
  10 in total
  14 in total

1.  Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone.

Authors:  Jeffry S Nyman; Jesse L Even; Chan-Hee Jo; Erik G Herbert; Matthew R Murry; Gael E Cockrell; Elizabeth C Wahl; R Clay Bunn; Charles K Lumpkin; John L Fowlkes; Kathryn M Thrailkill
Journal:  Bone       Date:  2010-12-23       Impact factor: 4.398

2.  Phalangeal quantitative ultrasound and metabolic control in pre-menopausal women with type 1 diabetes mellitus.

Authors:  A Catalano; N Morabito; G Di Vieste; B Pintaudi; D Cucinotta; A Lasco; A Di Benedetto
Journal:  J Endocrinol Invest       Date:  2012-10-01       Impact factor: 4.256

Review 3.  Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.

Authors:  Kathryn M Thrailkill; Charles K Lumpkin; R Clay Bunn; Stephen F Kemp; John L Fowlkes
Journal:  Am J Physiol Endocrinol Metab       Date:  2005-11       Impact factor: 4.310

4.  Effects of a high fat-sucrose diet on cortical bone morphology and biomechanics.

Authors:  K C Li; R F Zernicke; R J Barnard; A F Li
Journal:  Calcif Tissue Int       Date:  1990-11       Impact factor: 4.333

5.  Multiple fractures and impaired bone metabolism in Wolfram syndrome: a case report.

Authors:  Antonino Catalano; Federica Bellone; Giuseppe Cicala; Annalisa Giandalia; Nunziata Morabito; Domenico Cucinotta; Giuseppina Tiziana Russo
Journal:  Clin Cases Miner Bone Metab       Date:  2017-10-25

Review 6.  A new perspective on mechanisms governing skeletal complications in type 1 diabetes.

Authors:  Zeynep Seref-Ferlengez; Sylvia O Suadicani; Mia M Thi
Journal:  Ann N Y Acad Sci       Date:  2016-08-29       Impact factor: 5.691

7.  Bone mineral density in the femur and lumbar vertebrae decreases after twelve weeks of diabetes in spontaneously diabetic-prone BB/Worcester rats.

Authors:  C E Waud; S C Marks; R Lew; D T Baran
Journal:  Calcif Tissue Int       Date:  1994-03       Impact factor: 4.333

8.  Osteoporosis in type II diabetes.

Authors:  G Isaia; L Bodrato; V Carlevatto; M Mussetta; G Salamano; G M Molinatti
Journal:  Acta Diabetol Lat       Date:  1987 Oct-Dec

9.  Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life.

Authors:  Matthew J Silva; Michael D Brodt; Michelle A Lynch; Jennifer A McKenzie; Kristi M Tanouye; Jeffry S Nyman; Xiaodu Wang
Journal:  J Bone Miner Res       Date:  2009-09       Impact factor: 6.741

10.  THE EFFECT OF GLUCOVANCE THERAPY ON BIOMECHANICAL DETERIORATION OF BONE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.

Authors:  C Demirel; H Korkmaz; S Gurgul; A Yildiz; E Akarsu; N Erdal
Journal:  Acta Endocrinol (Buchar)       Date:  2019 Jul-Sep       Impact factor: 0.877
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