Literature DB >> 6775667

Haematoporphyrin diacetate: a probe to distinguish malignant from normal tissue by selective fluorescence.

R W Henderson, G S Christie, P S Clezy, J Lineham.   

Abstract

Haematoporphyrin diacetate has been synthesized and purified. Following introduction into mice bearing squamous-cell carcinomas it was found to produce a fluorescence of the tumour tissue which was much stronger than that of the surrounding normal tissue. Haematoporphyrin diacetate was also shown to be the major active component of the impure compound known as haematoporphyrin derivative which has been widely used in tumour fluorescence studies.

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Year:  1980        PMID: 6775667      PMCID: PMC2041603     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN: 0007-1021


  5 in total

1.  FURTHER EVALUATION OF THE USE OF HEMATOPORPHYRIN DERIVATIVE AS A NEW AID FOR THE ENDOSCOPIC DETECTION OF MALIGNANT DISEASE.

Authors:  R L LIPSON; E J BALDES; A M OLSEN
Journal:  Dis Chest       Date:  1964-12

2.  Hematoporphyrin-derivative-fluorescence test colposcopy and colpophotography in the diagnosis of atypical metaplasia, dysplasia, and carcinoma in situ of the cervix uteri.

Authors:  G A Kyriazis; H Balin; R L Lipson
Journal:  Am J Obstet Gynecol       Date:  1973-10-01       Impact factor: 8.661

3.  Hematoporphyrin-derivative fluorescence in malignant neoplasms.

Authors:  H B Gregorie; E O Horger; J L Ward; J F Green; T Richards; H C Robertson; T B Stevenson
Journal:  Ann Surg       Date:  1968-06       Impact factor: 12.969

4.  Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

Authors:  C J Gomer; T J Dougherty
Journal:  Cancer Res       Date:  1979-01       Impact factor: 12.701

5.  Photodynamic destruction of human bladder carcinoma.

Authors:  J F Kelly; M E Snell; M C Berenbaum
Journal:  Br J Cancer       Date:  1975-02       Impact factor: 7.640

  5 in total
  3 in total

1.  Haematoporphyrin and OO'-diacetylhaematoporphyrin binding by serum and cellular proteins. Implications for the clearance of these photochemotherapeutic agents by cells.

Authors:  A Smith; T Neuschatz
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

2.  Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase.

Authors:  H A Dailey; A Smith
Journal:  Biochem J       Date:  1984-10-15       Impact factor: 3.857

3.  In vivo biological activity of the components of haematoporphyrin derivative.

Authors:  M C Berenbaum; R Bonnett; P A Scourides
Journal:  Br J Cancer       Date:  1982-04       Impact factor: 7.640

  3 in total

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