Literature DB >> 6775350

Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition.

T J Carty, J S Stevens, J G Lombardino, M J Parry, M J Randall.   

Abstract

Piroxicam is a potent inhibitor of prostaglandin biosynthesis. Experiments utilizing cell culture and microsomes derived from various sources have demonstrated that piroxicam is a selective inhibitor of the cyclooxygenase step of arachidonic acid metabolism. Little blocking activity is observed at the phospholipase, thromboxane or prostacyclin synthetase, and arachidonic acid lipoxygenase steps.

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Year:  1980        PMID： 6775350     DOI： 10.1016/0090-6980(80)90166-5

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  14 in total

Review 1.  Treatment of dysmenorrhoea and premenstrual syndrome with non-steroidal anti-inflammatory drugs.

Authors:  S S Shapiro
Journal:  Drugs       Date:  1988-10       Impact factor: 9.546

2.  In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs.

Authors:  G Mallarkey; G M Smith
Journal:  Br J Pharmacol       Date:  1984-01       Impact factor: 8.739

3.  In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells.

Authors:  M Earashi; M Noguchi; M Tanaka
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

Review 4.  Piroxicam. A reappraisal of its pharmacology and therapeutic efficacy.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-10       Impact factor: 9.546

5.  Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam.

Authors:  T J Carty; A Marfat; P F Moore; F C Falkner; T M Twomey; A Weissman
Journal:  Agents Actions       Date:  1993-07

Review 6.  Non-steroidal anti-inflammatory analgesics other than salicylates.

Authors:  R N Brogden
Journal:  Drugs       Date:  1986       Impact factor: 9.546

Review 7.  Diverse effects of essential (n-6 and n-3) fatty acids on cultured cells.

Authors:  S I Grammatikos; P V Subbaiah; T A Victor; W M Miller
Journal:  Cytotechnology       Date:  1994       Impact factor: 2.058

8.  A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats.

Authors:  G Mallarkey; G M Smith
Journal:  Br J Pharmacol       Date:  1985-02       Impact factor: 8.739

9.  Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.

Authors:  X H Liu; J M Connolly; D P Rose
Journal:  Clin Exp Metastasis       Date:  1996-03       Impact factor: 5.150

Review 10.  Piroxicam: a review of its pharmacological properties and therapeutic efficacy.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-09       Impact factor: 9.546
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