Literature DB >> 6774418

Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat.

C Rivier, J Rivier, W Vale.   

Abstract

Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.

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Year:  1980        PMID： 6774418     DOI： 10.1126/science.6774418

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate.

Authors:  H Okada; T Heya; Y Ogawa; H Toguchi; T Shimamoto
Journal:  Pharm Res       Date:  1991-05       Impact factor: 4.200

2.  Suppression of meiosis of male germ cells by an antagonist of luteinizing hormone-releasing hormone.

Authors:  B Szende; T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

3.  Prostate carcinoma tumor size in rats decreases after administration of antagonists of luteinizing hormone-releasing hormone.

Authors:  T W Redding; D H Coy; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205
  3 in total

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