The prevention of cyclophosphamide-induced bladder swelling in the rat by I.V. administration of sodium-2-mercaptoethane sulfonate.

In a preliminary experiment the wet weight of the rat urinary bladder appeared to correlate with cyclophosphamide toxicity. The effect of a proposed antidote (SMES), given on various time schedules, was studied using the wet weight as a measure of toxicity. At a cose of 20 mg/kg/SMES it was found to neutralize the toxicity of 100 mg cytoxan only when given simultaneously. It is suggested that this model might be used in further studies.