Effects of aspirin on blood plasma levels of testosterone, LH and FSH in maturing male rats.

Effects of aspirin administration (5 mg/100 g body weight) for various days were observed on the hormonal levels of maturing male rats. Aspirin was given orally every day for 8, 15, 22 and 30 days. No change in the weights of testes, epididymis, prostate or seminal vesicles was observed after treatment. While aspirin administration for 8 days caused an increase in the plasma testosteone level with decrease in both LH and FSH levels, prolonged treatment for 15 days and more produced a reverse effect, viz. decrease in plasma testosterone and increase in plasma LH and FSH levels. Testicular ascorbic acid content was found to decrease on the 15th and the 22nd day of treatment. Testicular cholesterol was increased after 22nd and 30th days of treatment. Prostatic acid phosphatase activity decreased in all the treated groups. The possible significance of these findings is discussed.