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Literature DB >> 6773878

Biological and biochemical properties of a human uveal melanocyte-derived cell line.

F L Meyskens, E B Berglund, D F Saxe, B B Fuller, L Z Pacelli, J D Hall, C G Ray.

Abstract

A human uveal melanocyte-derived cell line (U1I) is described. The cell line has a doubling time of 27.2 hr, a plating efficiency on plastic surfaces of 10%, and a cloning efficiency in soft agar of < 0.1%. U1I displays marked chromosomal aneuploidy and sensitivity to ultraviolet light. Biochemical studies indicate the presence of tyrosinase, which is stimulated by several compounds, including theophylline, progesterone, and nerve growth factor.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6773878 DOI： 10.1007/bf02619312

Source DB: PubMed Journal: In Vitro ISSN： 0073-5655

17 in total

1. Cell division and metabolic activity of naevus cells. The relationships between anatomy and behaviour in moles.

Authors: C Bentley-Phillips; R Marks
Journal: Br J Dermatol Date: 1976-05 Impact factor: 9.302

2. The growth of mouse melanoma cells in hormone-supplemented, serum-free medium.

Authors: J P Mather; G H Sato
Journal: Exp Cell Res Date: 1979-04 Impact factor: 3.905

3. Tissue culture of human retinal pigment epithelium.

Authors: J Mannagh; D V Arya; A R Irvine
Journal: Invest Ophthalmol Date: 1973-01

4. Stimulation of dendritogenesis in human melanocytes by dibutyryl adenosine 3', 5'-cyclic monophosphate in vitro.

Authors: Y Kitano
Journal: Arch Dermatol Forsch Date: 1973-12-05

5. An improved technique for selective silver staining of nucleolar organizer regions in human chromosomes.

Authors: S E Bloom; C Goodpasture
Journal: Hum Genet Date: 1976-10-28 Impact factor: 4.132

6. Resistance of human melanoma cells to ultraviolet radiation.

Authors: A H Chalmers; M Lavin; S Atisoontornkul; J Mansbridge; C Kidson
Journal: Cancer Res Date: 1976-06 Impact factor: 12.701

7. Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro.

Authors: Y Kitano
Journal: Arch Dermatol Res Date: 1976-11-26 Impact factor: 3.017

Biological and biochemical properties of a human uveal melanocyte-derived cell line.

1. Cell division and metabolic activity of naevus cells. The relationships between anatomy and behaviour in moles.

2. The growth of mouse melanoma cells in hormone-supplemented, serum-free medium.

3. Tissue culture of human retinal pigment epithelium.

4. Stimulation of dendritogenesis in human melanocytes by dibutyryl adenosine 3', 5'-cyclic monophosphate in vitro.

5. An improved technique for selective silver staining of nucleolar organizer regions in human chromosomes.

6. Resistance of human melanoma cells to ultraviolet radiation.

7. Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro.

8. The use of agarose in the determination of anchorage-independent growth.

9. Human malignant melanoma cell lines.

10. Molecular biology of pigment cells. Molecular controls in mammalian pigmentation.

1. Serum-free cultivation of adult normal human choroidal melanocytes.

2. Modulation of clonogenic human melanoma cells by follicle-stimulating hormone, melatonin, and nerve growth factor.