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Literature DB >> 67723

[The effect of bleomycin, ICRF 159 and of simultaneous X-ray application on CHO-fibroblasts].

Abstract

The cell damage of the cytostatics Bleomycin and ICRF 159 were studied experimentally by the use of the following parameters: colony survival, colony-size-spectrometry and multiplicity of CHO-Fibroblasts. Series of increasing drug concentrations and simultaneous irradiation with 200 rds were measured. In the above mentioned tests an additive and no potentiating effect of damage by the cytostatics in combination with irradiation of 200 rds was found. Compared with Bleomycin, ICRF 159 showed a higher degree of damage to CHO-Fibroblasts.

Entities: Chemical

Mesh：

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Year: 1977 PMID： 67723 DOI： 10.1007/BF00305367

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

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References

20 in total

1. [Colony size spectra of 60Co-gamma-irridiated CHO fibroblasts following freeze and thaw cycles].

Authors: D Töllner; H Nachtegal; G Hagemann; J Deinhardt
Journal: Strahlentherapie Date: 1975-05

2. Effects of bleomycin on progression through the cell cycle of mouse L-cells.

Authors: M Watanabe; Y Takabe; T Katsumata; T Terasima
Journal: Cancer Res Date: 1974-04 Impact factor: 12.701

3. Response in macromolecular syntheses of mouse L cells to bleomycin, with special reference to cell-antibiotic interaction.

Authors: M Watanabe; Y Takabe; T Katsumata; T Terasima; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1973-08 Impact factor: 2.649

[The effect of bleomycin, ICRF 159 and of simultaneous X-ray application on CHO-fibroblasts].

1. [Colony size spectra of 60Co-gamma-irridiated CHO fibroblasts following freeze and thaw cycles].

2. Effects of bleomycin on progression through the cell cycle of mouse L-cells.

3. Response in macromolecular syntheses of mouse L cells to bleomycin, with special reference to cell-antibiotic interaction.

4. Action of actinomycin D, bleomycin and x rays on HeLa cells.

5. Radiosensitization of bleomycin on lethal effect of mouse cancer cell in vitro.

6. The effects of bleomycin on survival and cell progression in Chinese hamster cells in vitro.

7. Combined treatment of the Walker tumour with radiotherapy and ICRF 159.

8. Radiation-induced division delay in synchronized Chinese hamster ovary cells in monolayer culture.

9. [Radiotherapy and ECRF 159 (NCS 129943) in the treatment of inoperable soft-tissue sarcoma (author's transl)].

10. New antibiotics, bleomycin A and B.