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Literature DB >> 6772153

Isoenzymes of membrane-bound beta-glucosidase of human spleen.

Abstract

Normal human spleen contains two forms of membrane-bound beta-glucosidase, distinguishable by their thermostability and kinetic properties. The spleen from a patient with adult Gaucher's disease was deficient in the major, thermolabile, form of the enzyme.

Entities: Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6772153 PMCID： PMC1161386 DOI： 10.1042/bj1850541

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

10 in total

1. METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.

Authors: R O BRADY; J N KANFER; D SHAPIRO
Journal: Biochem Biophys Res Commun Date: 1965-01-18 Impact factor: 3.575

2. Synthesis and processing of protein-linked oligosaccharides in vivo.

Authors: S C Hubbard; P W Robbins
Journal: J Biol Chem Date: 1979-06-10 Impact factor: 5.157

3. Solubilization of glucocerebrosidase from human placenta and demonstration of a phospholipid requirement for its catalytic activity.

Authors: G L Dale; D G Villacorte; E Beutler
Journal: Biochem Biophys Res Commun Date: 1976-08-23 Impact factor: 3.575

4. Acid beta-glucosidase and the diagnosis of Gaucher's disease in liver and spleen.

Authors: J Butterworth; D M Broadhead
Journal: Clin Chim Acta Date: 1978-08-01 Impact factor: 3.786

5. Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue.

Authors: P G Pentchev; R O Brady; H E Blair; D E Britton; S H Sorrell
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

6. Activation of membrane-bound glucosylceramide: beta-glucosidase in fibroblasts cultured from normal and glucosylceramidotic human skin.

Authors: O T Mueller; A Rosenberg
Journal: J Biol Chem Date: 1979-05-10 Impact factor: 5.157

4 in total

Isoenzymes of membrane-bound beta-glucosidase of human spleen.

1. METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.

2. Synthesis and processing of protein-linked oligosaccharides in vivo.

3. Solubilization of glucocerebrosidase from human placenta and demonstration of a phospholipid requirement for its catalytic activity.

4. Acid beta-glucosidase and the diagnosis of Gaucher's disease in liver and spleen.

5. Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue.

6. Activation of membrane-bound glucosylceramide: beta-glucosidase in fibroblasts cultured from normal and glucosylceramidotic human skin.

7. The diagnosis of Gaucher's disease in liver using 4-methylumbelliferyl-beta-D-glucopyranoside.

8. Cell-specific differences in membrane beta-glucosidase from normal and Gaucher cells.

9. Identity of 'acid' beta-glucosidase and glucocerebrosidase in human spleen.

10. Steroid beta-D-glucosidase in steer liver and kidney.

1. Genetic heterogeneity of membrane-bound beta-glucosidase in Gaucher's disease.

2. Physical and kinetic properties of beta-glucosidase in Gaucher disease.

3. Mutations of glucocerebrosidase: discrimination of neurologic and non-neurologic phenotypes of Gaucher disease.

4. Gaucher disease (type 1): physical and kinetic properties of liposomal and soluble 'acid' beta-glucosidase.