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Literature DB >> 6771794

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat.

J J Balsara, J H Jadhav, A G Chandorkar.

Abstract

Pretreatment with GABA (250--1,000 mg/kg IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.

Entities: Chemical Disease Species

Mesh：

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Year: 1980 PMID： 6771794 DOI： 10.1007/bf00426658

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

15 in total

1. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors: A CARLSSON; M LINDQVIST
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1963

2. [IMMEDIATE CLINICAL RESULTS WITH GAMMA AMINOBUTYRIC ACID B6 IN SCHIZOPHRENIAS AND DELIRIUMS].

Authors: O B MORRONI
Journal: Sem Med Date: 1963-09-16

3. On the efficacy of asparagine, glutamine, gamma-aminobutyric acid and 1-pyrroiidinone in preventing chemically induced seizures in mice.

Authors: J E HAWKINS; L H SARETT
Journal: Clin Chim Acta Date: 1957-12 Impact factor: 3.786

4. The effect of intraperitoneally administered GABA on brain monoamine metabolism.

Authors: B Biswas; A Carlsson
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-08 Impact factor: 3.000

5. GABA involvement in neuroleptic-induced catalepsy.

Authors: P Worms; M T Willigens; K G Lloyd
Journal: J Pharm Pharmacol Date: 1978-11 Impact factor: 3.765

Review 6. Pharmacological actions of gamma-aminobutyric acid, a review article.

Authors: S F Saad
Journal: Mater Med Pol Date: 1978 Jan-Mar

7. Inhibitory effect of gammahydroxybutyric acid and gammaaminobutyric acid on the dopamine cells in the substantia nigra.

Authors: N E Andén; G Stock
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat.

1. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

2. [IMMEDIATE CLINICAL RESULTS WITH GAMMA AMINOBUTYRIC ACID B6 IN SCHIZOPHRENIAS AND DELIRIUMS].

3. On the efficacy of asparagine, glutamine, gamma-aminobutyric acid and 1-pyrroiidinone in preventing chemically induced seizures in mice.

4. The effect of intraperitoneally administered GABA on brain monoamine metabolism.

5. GABA involvement in neuroleptic-induced catalepsy.

Review 6. Pharmacological actions of gamma-aminobutyric acid, a review article.

7. Inhibitory effect of gammahydroxybutyric acid and gammaaminobutyric acid on the dopamine cells in the substantia nigra.

8. Blood-brain barrier to H3-gamma-aminobutyric acid in normal and amino oxyacetic acid-treated animals.

9. Interaction of benzodiazepines with neuroleptics at central dopamine neurons.

10. Effect of intraperitoneally administered GABA on the locomotor activity of mice.

1. Parametric influences on catalepsy.

2. Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats.