Literature DB >> 6771778

Inhibition of human platelet cyclooxygenase by alpha-tocopherol.

M Ali, C G Gudbranson, J W McDonald.   

Abstract

Alpha-tocopherol, an inhibitor of platelet aggregation, was evaluated for its effects on the synthesis of thromboxane and prostaglandins. A dose-dependent reduction in thromboxane B2 and prostaglandin D2 synthesis was observed with approximately 60% inhibition at 5.0 IU or alpha-tocopherol. Alpha-tocopherol produced a time-dependent, irreversible inhibition.

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Year:  1980        PMID: 6771778     DOI: 10.1016/0161-4630(80)90038-5

Source DB:  PubMed          Journal:  Prostaglandins Med        ISSN: 0161-4630


  2 in total

1.  In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution.

Authors:  C Douillet; M Bost; M Accominotti; F Borson-Chazot; M Ciavatti
Journal:  Biol Trace Elem Res       Date:  1996-12       Impact factor: 3.738

2.  Modulation of the platelet thromboxane A2 and aortic prostacyclin synthesis by dietary selenium and vitamin E.

Authors:  M Meydani
Journal:  Biol Trace Elem Res       Date:  1992 Apr-Jun       Impact factor: 3.738

  2 in total

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