Literature DB >> 677123

Ethnic variation of genetic disease: roles of drift for recessive lethal genes.

D Wagener, L L Cavalli-Sforza, R Barakat.   

Abstract

Using Wright's distribution of gene frequencies for a recessive lethal gene, a method is given to analyze the probability that any particular gene frequency is greater than a given threshold gene frequency. The method is introduced to analyze the plausibility of drift for explaining observed data.

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Mesh：

Year:  1978        PMID： 677123      PMCID： PMC1685590     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  Infantile amaurotic family idiocy; a genetic approach.

Authors:  P J KOZINN; H WIENER; P COHEN
Journal:  J Pediatr       Date:  1957-07       Impact factor: 4.406

2.  The Distribution of Gene Frequencies in Populations.

Authors:  S Wright
Journal:  Proc Natl Acad Sci U S A       Date:  1937-06       Impact factor: 11.205

3.  Tay-Sachs disease: genetic drift among the Ashkenazim Jews.

Authors:  A L Fraikor
Journal:  Soc Biol       Date:  1977

Review 4.  Cystic fibrosis: population genetics.

Authors:  P M Conneally; A D Merritt; P L Yu
Journal:  Tex Rep Biol Med       Date:  1973

5.  Large deviations in the distribution of rare genes.

Authors:  D C Rao; N E Morton
Journal:  Am J Hum Genet       Date:  1973-11       Impact factor: 11.025

6.  Ethnic distribution of disease in non-Jews.

Authors:  V A McKusick
Journal:  Isr J Med Sci       Date:  1973 Sep-Oct

7.  Controversy in human genetics: founder effect in Tay-Sachs disease.

Authors:  G A Chase; V A McKusick
Journal:  Am J Hum Genet       Date:  1972-05       Impact factor: 11.025

8.  Is Tay-Sachs disease increasing?

Authors:  R F Shaw; A P Smith
Journal:  Nature       Date:  1969-12-20       Impact factor: 49.962

9.  Tay-Sachs disease is probably not increasing.

Authors:  N C Myrianthopoulos; A F Naylor; S M Aronson
Journal:  Nature       Date:  1970-08-08       Impact factor: 49.962

10.  Ethnic variation in genetic disease: possible roles of hitchhiking and epistasis.

Authors:  D K Wagener; L L Cavalli-Sforza
Journal:  Am J Hum Genet       Date:  1975-05       Impact factor: 11.025
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  11 in total

1.  Geographic distribution of disease mutations in the Ashkenazi Jewish population supports genetic drift over selection.

Authors:  Neil Risch; Hua Tang; Howard Katzenstein; Josef Ekstein
Journal:  Am J Hum Genet       Date:  2003-02-24       Impact factor: 11.025

2.  Marital mores as a mechanism for the maintenance of ethnic variations of lethal gene frequencies.

Authors:  D B McCormick; S R Schach; J H Koeslag
Journal:  Am J Hum Genet       Date:  1986-10       Impact factor: 11.025

3.  Differences in the frequency of X-linked deleterious genes in human populations.

Authors:  A Chakravarti; S J Bale
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

4.  Tay-Sachs disease and theoretical population genetics.

Authors:  W J Ewens
Journal:  Am J Hum Genet       Date:  1978-05       Impact factor: 11.025

5.  Heterozygote advantage in Tay-Sachs carriers?

Authors:  B Spyropoulos; P B Moens; J Davidson; J A Lowden
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025

6.  Reduction of bias in estimating the frequency of recessive genes.

Authors:  C A Huether; E A Murphy
Journal:  Am J Hum Genet       Date:  1980-03       Impact factor: 11.025

7.  Population genetic aspects of primary congenital glaucoma. II. Fitness, parental consanguinity, founder effect.

Authors:  V Ferák; A Gencik; A Gencikova
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

8.  Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis.

Authors:  Amos Frisch; Roberto Colombo; Elena Michaelovsky; Mazal Karpati; Boleslaw Goldman; Leah Peleg
Journal:  Hum Genet       Date:  2004-01-15       Impact factor: 4.132

9.  A population-based study of autosomal-recessive disease-causing mutations in a founder population.

Authors:  Jessica X Chong; Rebecca Ouwenga; Rebecca L Anderson; Darrel J Waggoner; Carole Ober
Journal:  Am J Hum Genet       Date:  2012-09-13       Impact factor: 11.025

10.  Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.

Authors:  Kate M Im; Tomas Kirchhoff; Xianshu Wang; Todd Green; Clement Y Chow; Joseph Vijai; Joshua Korn; Mia M Gaudet; Zachary Fredericksen; V Shane Pankratz; Candace Guiducci; Andrew Crenshaw; Lesley McGuffog; Christiana Kartsonaki; Jonathan Morrison; Sue Healey; Olga M Sinilnikova; Phuong L Mai; Mark H Greene; Marion Piedmonte; Wendy S Rubinstein; Frans B Hogervorst; Matti A Rookus; J Margriet Collée; Nicoline Hoogerbrugge; Christi J van Asperen; Hanne E J Meijers-Heijboer; Cees E Van Roozendaal; Trinidad Caldes; Pedro Perez-Segura; Anna Jakubowska; Jan Lubinski; Tomasz Huzarski; Paweł Blecharz; Heli Nevanlinna; Kristiina Aittomäki; Conxi Lazaro; Ignacio Blanco; Rosa B Barkardottir; Marco Montagna; Emma D'Andrea; Peter Devilee; Olufunmilayo I Olopade; Susan L Neuhausen; Bernard Peissel; Bernardo Bonanni; Paolo Peterlongo; Christian F Singer; Gad Rennert; Flavio Lejbkowicz; Irene L Andrulis; Gord Glendon; Hilmi Ozcelik; Amanda Ewart Toland; Maria Adelaide Caligo; Mary S Beattie; Salina Chan; Susan M Domchek; Katherine L Nathanson; Timothy R Rebbeck; Catherine Phelan; Steven Narod; Esther M John; John L Hopper; Saundra S Buys; Mary B Daly; Melissa C Southey; Mary-Beth Terry; Nadine Tung; Thomas V O Hansen; Ana Osorio; Javier Benitez; Mercedes Durán; Jeffrey N Weitzel; Judy Garber; Ute Hamann; Susan Peock; Margaret Cook; Clare T Oliver; Debra Frost; Radka Platte; D Gareth Evans; Ros Eeles; Louise Izatt; Joan Paterson; Carole Brewer; Shirley Hodgson; Patrick J Morrison; Mary Porteous; Lisa Walker; Mark T Rogers; Lucy E Side; Andrew K Godwin; Rita K Schmutzler; Barbara Wappenschmidt; Yael Laitman; Alfons Meindl; Helmut Deissler; Raymonda Varon-Mateeva; Sabine Preisler-Adams; Karin Kast; Laurence Venat-Bouvet; Dominique Stoppa-Lyonnet; Georgia Chenevix-Trench; Douglas F Easton; Robert J Klein; Mark J Daly; Eitan Friedman; Michael Dean; Andrew G Clark; David M Altshuler; Antonis C Antoniou; Fergus J Couch; Kenneth Offit; Bert Gold
Journal:  Hum Genet       Date:  2011-05-20       Impact factor: 4.132
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