Literature DB >> 677105

Effect of N-methyl-N'-nitro-N-nitrosoguanidine on the gastric mucosal barrier in rats.

I Horowitz, L S Toth, J L Werther.   

Abstract

The gastric mucosal barrier to hydrogen ion (H+) after the administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the rat stomach was studied. Increased H+ back-diffusion was observed 3 hr after oral doses of 1 mg of MNNG over a 3-day period. MNNG in concentrations of 250 microgram/ml, 167 microgram/ml, 86 microgram/ml, and 50 microgram/ml in the presence of acid caused increased H+ back-diffusion across the gastric mucosa within 1 hr. Gastric mucosal barrier disruption by MNNG may play a pathogenic role in gastric carcinogenesis.

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Year:  1978        PMID： 677105     DOI： 10.1007/BF01072694

Source DB:  PubMed          Journal:  Am J Dig Dis        ISSN： 0002-9211


  7 in total

1.  Sequential morphological changes in N-methyl-N'-nitro-N-nitrosoguanidine carcinogenesis in the glandular stomach of rats.

Authors:  T Saito; K Inokuchi; S Takayama; T Sugimura
Journal:  J Natl Cancer Inst       Date:  1970-04       Impact factor: 13.506

2.  The effect of stress on the gastric mucosal barrier in rats.

Authors:  J L Werther; I Horowitz
Journal:  Proc Soc Exp Biol Med       Date:  1977-03

3.  Possible role of mucosal damage in stomach carcinogenesis with N-methyl-N-nitro-N-nitrosoguanidine in the rat.

Authors:  Y Tabuchi; T Ogino; T Mitsuno; T Sugiyama
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

4.  Adenocarcinoma of glandular stomach and duodenum in Wistar rats ingesting N-methyl-N'-nitro-N-nitrosoguanidine, histopathology and associated secretory changes.

Authors:  S P Bralow; M Gruenstein; D R Meranze; A Bonakdarpour; M B Shimkin
Journal:  Cancer Res       Date:  1970-05       Impact factor: 12.701

5.  Restraint-induced gastric erosions. Role of acid back diffusion.

Authors:  D C Gerety; P H Guth
Journal:  Am J Dig Dis       Date:  1972-11

6.  Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  T Sugimura; S Fujimura; T Baba
Journal:  Cancer Res       Date:  1970-02       Impact factor: 12.701

7.  Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  T Sugimura; S Fujimura
Journal:  Nature       Date:  1967-12-02       Impact factor: 49.962
  7 in total

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