Literature DB >> 6770466

Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene.

J M Backer, I B Weinstein.   

Abstract

When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.

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Year:  1980        PMID： 6770466     DOI： 10.1126/science.6770466

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

1.  Detection of a specific mitochondrial DNA deletion in tissues of older humans.

Authors:  G A Cortopassi; N Arnheim
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

2.  Evaluation of mitochondrial content and activity with nonyl-acridine orange and rhodamine 123: flow cytometric analysis and comparison with quantitative morphometry. Comparative analysis by flow cytometry and quantitative morphometry of mitochondrial content and activity.

Authors:  G Lizard; Y Chardonnet; M C Chignol; J Thivolet
Journal:  Cytotechnology       Date:  1990-03       Impact factor: 2.058

Review 3.  Repair of mtDNA in vertebrates.

Authors:  D F Bogenhagen
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

Review 4.  Mitochondrial DNA damage and its consequences for mitochondrial gene expression.

Authors:  Susan D Cline
Journal:  Biochim Biophys Acta       Date:  2012-06-19

5.  Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents.

Authors:  Jason F Harrison; Mikael L Rinne; Mark R Kelley; Nadiya M Druzhyna; Glenn L Wilson; Susan P Ledoux
Journal:  Glia       Date:  2007-11-01       Impact factor: 7.452

6.  Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA.

Authors:  Frederick J Lariviere; Adam G Newman; Megan L Watts; Sharonda Q Bradley; Justin E Juskewitch; Paul G Greenwood; Julie T Millard
Journal:  Mutat Res       Date:  2009-02-21       Impact factor: 2.433

7.  Efficient repair of abasic sites in DNA by mitochondrial enzymes.

Authors:  K G Pinz; D F Bogenhagen
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

8.  Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes).

Authors:  Meryl D Colton; Kevin W H Kwok; Jennifer A Brandon; Isaac H Warren; Ian T Ryde; Ellen M Cooper; David E Hinton; Daniel Rittschof; Joel N Meyer
Journal:  Mar Environ Res       Date:  2014-04-26       Impact factor: 3.130

9.  Mutation of mitochondria genome: trigger of somatic cell transforming to cancer cell.

Authors:  Du Jianping
Journal:  Int Arch Med       Date:  2010-02-05

Review 10.  QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology.

Authors:  Joel N Meyer
Journal:  Ecotoxicology       Date:  2010-01-05       Impact factor: 2.823
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